For a long time, researchers and clinicians have strictly divided fatty liver diseases into alcoholic and non-alcoholic fatty liverdisease. When one was diagnosed as alcoholic liver disease, the effects of non-alcoholic factors, including obesity, diabetes or metabolicsyndrome, on liver diseases have been neglected. Conversely, when the patient was diagnosed as non-alcoholic fatty liver disease, the im-pacts of alcohol drinking are usually ignored. In the new era, physicians and scientific researchers need to pay more attention to the dual fac-tors of alcohol and obesity, which often exist together and affect liver disease progression. This article elaborates on the clinical features of fat-ty liver disease in the new era from the aspects of changes in the clinical features of alcoholic liver disease, disease pattern of nonalcoholicfatty liver disease with drinking, and differential diagnosis of alcoholic and nonalcoholic fatty liver diseases.