HDV感染的流行病学、发病机制及诊疗进展

王宇; 陈小华; 赵志敏; 黄恺; 刘成海

doi:10.3969/j.issn.1001-5256.2019.03.040

HDV感染的流行病学、发病机制及诊疗进展

DOI: 10.3969/j.issn.1001-5256.2019.03.040

1. 上海中医药大学附属曙光医院肝病研究所
2. 上海市第六人民医院感染科

详细信息

中图分类号: R512.6;R181.3
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出版历程
- 收稿日期: 2018-09-18
- 出版日期: 2019-03-20

Research advances in epidemiology, pathogenesis, and diagnosis and treatment of hepatitis D virus infection

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

摘要

摘要: HBV/HDV合并感染可导致肝病进展加速,但由于HDV RNA等检测方法学尚存在一定局限,HDV的流行病学尚不十分清楚; HDV导致HBV/HDV共感染者的发病机制及其治疗措施也需要进一步探讨。通过回顾我国以及其他国家HDV流行病学特征、HDV特异性免疫与基因型发病机制,并总结HDV的检测方法及治疗方法,分析表明现有HDV感染的检测方法敏感度、特异度低,也无标准化检测方法;探究新的HDV感染检测方法,将有助于研发新型有效抗的HDV药物,对提高HDV感染的疗效具有重要意义。
- 肝炎病毒,δ /
- 流行病学 /
- 诊断 /
- 治疗学 /
- 综述
Abstract: Hepatitis B virus ( HBV) /hepatitis D virus ( HDV) co-infection can accelerate the progression of liver diseases, but due to thelimitations of the detection methods for HDV RNA, the epidemiology of HDV remains unclear. Further studies are needed to investigate thepathogenesis of HBV/HDV co-infection caused by HDV and related treatment methods. By reviewing the epidemiological features of HDV, HDV-specific immunity, genotype, and pathogenesis in China and other countries and summarizing HDV detection methods and treatmentmethods, this article shows that current detection methods for HDV infection have low sensitivity and specificity, with a lack of standardizeddetection methods. Exploration of new HDV detection methods will help to develop new and effective anti-HDV drugs, which has great sig-nificance in improving the outcome of HDV infection.
- hepatitis delta virus /
- epidemiology /
- diagnosis /
- therapeutics /
- review

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