肝星状细胞的活化机制—探寻肝纤维化新的诊断指标和治疗靶点

姜娜; 平键; 徐列明

doi:10.3969/j.issn.1001-5256.2019.03.042

肝星状细胞的活化机制—探寻肝纤维化新的诊断指标和治疗靶点

DOI: 10.3969/j.issn.1001-5256.2019.03.042

1. 上海中医药大学附属曙光医院
2. 上海中医药大学肝病研究所
3. 肝肾疾病病证教育部重点实验室
4. 上海市中医临床重点实验室
5. 国家中医药管理局重点研究室(慢性肝病虚损)

基金项目:

国家自然科学基金资助项目(81373859)；

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2018-08-30
- 出版日期: 2019-03-20

Mechanism of the activation of hepatic stellate cells:An exploration of new diagnostic markers and therapeutic targets for liver fibrosis

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 肝纤维化的形成机制复杂,目前主流研究依然围绕肝星状细胞(HSC)开展,并发现许多促进HSC活化的刺激因子和调节通路。对影响HSC的几种主要细胞因子和过氧化物酶体增殖物激活受体γ相关近期研究结果以及近年的研究热点——小RNA、长非编码RNA、外泌体等与HSC活化的关系进行综述,旨在介绍治疗肝纤维化的潜在新靶点和非侵入性肝病诊断的新检测指标,提出将作用于HSC活化的不同靶点的化学药物或中药成分合理组成复方,以期在肝纤维化治疗学上有所突破的观点。
- 肝星状细胞 /
- 细胞因子类 /
- 过氧化物酶体增殖物激活受体 /
- 微RNAs /
- 综述
Abstract: Liver fibrosis has a complex pathogenesis, and at present, the research mainly focuses on hepatic stellate cells ( HSC) . Many stim-ulating factors and regulatory pathways have been found to promote the activation of HSC. This article reviews the recent research findings onseveral major cytokines and peroxisome proliferator-activated receptor γ and research hotspots in recent years, including the association of mi-croRNAs, long non-coding RNA, and exosomes with HSC activation. This article also introduces potential targets for the treatment of liver fi-brosis and new markers for noninvasive diagnosis of liver diseases and proposes that chemical drugs or traditional Chinese medicine compoundswhich act on the targets of HSC activation can be formulated, in order to make a breakthrough in the therapeutics of liver fibrosis.
- hepatic stellate cells /
- cytokines /
- peroxisome proliferator-activated receptors /
- microRNAs /
- review

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参考文献(40)

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