上皮-间质转化相关长链非编码RNA在肝癌中的生物学功能及调控机制

王元; 郭涛; 李靖华; 赵继森; 周元龙; 杨季红

doi:10.3969/j.issn.1001-5256.2019.03.046

上皮-间质转化相关长链非编码RNA在肝癌中的生物学功能及调控机制

DOI: 10.3969/j.issn.1001-5256.2019.03.046

河北大学附属医院肝胆外科

基金项目:

河北省政府资助临床医学优秀人才培养和基础课题研究项目计划(冀财社〔2017〕46号)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2018-11-13
- 出版日期: 2019-03-20

Biological function and regulatory mechanism of epithelial-mesenchymal transition-related long non-coding RNAs in liver cancer

Department of Hepatobiliary Surgery, The Affiliated Hospital of Hebei University

Research funding:

摘要

摘要: 肝癌恶性程度较高,许多癌基因及抑癌基因在肝癌发生发展过程中发挥重要的调控作用。细胞由上皮表型向间质表型转化的过程称为上皮-间质转化（EMT）,可以增加肿瘤细胞迁移侵袭能力,长链非编码RNA能够通过多种方式调控EMT过程。综述了EMT相关长链非编码RNA在肝癌中的主要生物学功能以及调控机制的研究进展。
- 肝肿瘤 /
- 癌基因 /
- 长链非编码RNA /
- 上皮细胞 /
- 间质细胞 /
- 细胞转化,肿瘤 /
- 综述
Abstract: Liver cancer has a high degree of malignancy, and many oncogenes and tumor suppressor genes play an important regulatory rolein the development and progression of liver cancer. Epithelial-mesenchymal transition ( EMT) is a biological process in which epithelialcells transform into mesenchymal cells, which can increase the migration and invasion abilities of tumor cells. Long non-coding RNAs ( ln-cRNAs) can regulate EMT process in various ways. This article reviews the research advances in the main biological functions and regulatorymechanisms of EMT-related lncRNAs in liver cancer.
- liver neoplasms /
- oncogenes /
- lncRNA /
- epithelial cells /
- stromal cells /
- cell transformation, neoplastic /
- review

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