原发性胆汁性胆管炎合并干燥综合征及免疫性血小板减少症1例报告

陈庆灵; 蒉乙文; 仲瑞; 杨倩倩; 张晓雪; 温晓玉; 禹成男; 金清龙

doi:10.3969/j.issn.1001-5256.2019.07.037

原发性胆汁性胆管炎合并干燥综合征及免疫性血小板减少症1例报告

DOI: 10.3969/j.issn.1001-5256.2019.07.037

朝鲜民主主义人民共和国清津医科大学消化内科
吉林大学第一医院 a.肝胆胰内科； b.神经内科

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中图分类号: R575.7;R593.2;R558.2
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出版历程
- 出版日期: 2019-07-20

Primary biliary cholangitis with Sjogren's syndrome and immune thrombocytopenia: A case report

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

摘要

摘要:
<正>原发性胆汁性胆管炎（PBC）是一种慢性进行性自身免疫性肝病,是以肝内小胆管破坏为主要特征的慢性胆汁淤积性疾病[1]。PBC可合并多种自身免疫性疾病,包括干燥综合征（sj9gren’s syndrome,SS）、类风湿性关节炎、免疫性血小板减少症（immune thrombocytopenia,ITP）、溶血性贫血和系统性硬化症等,其中以SS最常见,而合并ITP者少见。PBC同时合并SS及ITP者更为少见,国内外均罕见报道。现报道PBC合并SS及ITP 1例,以期提高临床医生对该病的认识。
- 肝硬化,胆汁性 /
- 干燥综合征 /
- 血小板减少
- liver cirrhosis, biliary /
- Sjogren's syndrome /
- thrombocytopenia

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参考文献(14)

[1]PANDIT S, SAMANT H.Primary biliary cholangitis (primary biliary cirrhosis) [M].Treasure Istand:Sta Pearls Publishing, 2019.

[2]LINDOR KD, BOWLUS CL, BOYER J, et al.Primary biliary cholangitis:2018 practice guidance from the American Association for the Study of Liver Diseases[J].Hepatology, 2019, 69 (1) :394-419.

[3]TIAN H.Rheumatic and skin manifestations associated with autoimmune liver diseases[J].J Clin Hepatol, 2018, 34 (9) :2021-2026. (in Chinese) 田辉.自身免疫性肝病相关性风湿病样及皮肤表现[J].临床肝胆病杂志, 2018, 34 (9) :2021-2026.

[4]de SANTIS M, CROTTI C, SELMI C.Liver abnormalities in connective tissue diseases[J].Best Pract Res Clin Gastroenterol, 2013, 27 (4) :543-551.

[5]Chinese Rheumatology Association.Guidelines for the diagnosis and treatment of sicca syndrome[J].Chin J Rheumatol, 2010, 14 (11) :766-768. (in Chinese) 中华医学会风湿病学分会.干燥综合征诊断及治疗指南[J].中华风湿病学杂志, 2010, 14 (11) :766-768.

[6]GONZALEZ-LOPEZ TJ, ALVAREZ-ROMAN MT, PASCUALC, et al.Use of eltrombopag for secondary immune thrombocytopenia in clinical practice[J].Br J Haematol, 2017, 178 (6) :959-970.

[7]AFDHAL N, McHUTCHISON J, BROWN R, et al.Thrombocytopenia associated with chronic liver disease[J].J Hepatol, 2008, 48 (6) :1000-1007.

[8]MARKS PW.Hematologic manifestations of liver disease[J].Semin Hematol, 2013, 50 (3) :216-221.

[9]ZHAO ZB, LIAN ZX.Immunological pathogenesis of primary biliary cholangitis[J].J Clin Hepatol, 2017, 33 (11) :2112-2116. (in Chinese) 赵志斌, 廉哲雄.原发性胆汁性胆管炎的免疫学发病机制[J].临床肝胆病杂志, 2017, 33 (11) :2112-2116.

[10]BASSENDINE MF, COLLINS JD, STEPHENSON J, et al.Platelet associated immunoglobulins in primary biliary cirrhosis:A cause of thrombocytopenia?[J].Gut, 1985, 26 (10) :1074-1079.

[11]FEISTAUER SM, PENNER E, MAYR WR, et al.Target platelet antigens of autoantibodies in patients with primary biliary cirrhosis[J].Hepatology, 1997, 25 (6) :1343-1345.

[12]NEUNERT C, LIM W, CROWTHER M, et al.The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia[J].Blood, 2011, 117 (16) :4190-4207.

[13]ARNAL C, PIETTE JC, LEONE J, et al.Treatment of severe immune thrombocytopenia associated with systemic lupus erythematosus:59 cases[J].J Rheumatol, 2002, 29 (1) :75-83.

[14]VISCO C, RUGGERI M, LAURA EM, et al.Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia[J].Blood, 2008, 111 (3) :1110-1116.

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