缺氧诱导因子1α在肝纤维化发生发展中的作用机制

周丹; 张立婷; 李俊峰; 王珊; 肖萍

doi:10.3969/j.issn.1001-5256.2019.07.039

缺氧诱导因子1α在肝纤维化发生发展中的作用机制

DOI: 10.3969/j.issn.1001-5256.2019.07.039

兰州大学第一临床医学院
兰州大学第一医院 a.感染科, b.感染科研究所
兰州大学第一医院东岗院区肝病科

基金项目:

国家自然科学基金项目(31570509);国家自然科学基金项目(81800528)；甘肃省科技重大专项(1602FKDA001)；甘肃省生物治疗与再生医学重点实验室开放课题(zdsyskfkt-201701)；

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2019-01-21
- 出版日期: 2019-07-20

Mechanism of action of hypoxia-inducible factor 1α in the development and progression of liver fibrosis

The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China

Research funding:

摘要

摘要:
肝纤维化及终末期肝硬化常伴随肝脏缺氧现象,缺氧诱导因子1α作为调控机体缺氧反应的关键转录因子,在肝星状细胞活化和肝纤维化发生发展中扮演重要角色。此外,缺氧诱导因子1α表达下调可减轻肝纤维化,有望成为肝纤维化治疗新靶点。综述了缺氧诱导因子1α与肝纤维化相关信号通路及基因之间的关系,进一步讨论了缺氧诱导因子1α作为肝纤维化治疗新靶点的潜力。
- 缺氧诱导因子1,α亚基 /
- 肝硬化 /
- 信号传导
Abstract:
Liver fibrosis and end-stage liver cirrhosis are often accompanied by liver hypoxia. As a key transcription factor for regulating the body's response to hypoxia, hypoxia-inducible factor 1α ( HIF-1α) plays an important role in the activation of hepatic stellate cells and the development and progression of liver fibrosis. In addition, downregulation of HIF-1α expression can alleviate liver fibrosis and thus HIF-1α is expected to become a new target for the treatment of liver fibrosis. This article reviews the association between HIF-1α and liver fibrosis-related signaling pathways and genes and further discusses the potential of HIF-1α as a new therapeutic target for liver fibrosis.
- hypoxia-inducible factor 1, alpha subunit /
- liver fibrosis /
- signal transduction

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参考文献(32)

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