慢加急性肝衰竭合并严重骨髓抑制1例报告

赖长祥; 王方; 王松; 李知玉

doi:10.3969/j.issn.1001-5256.2019.09.034

慢加急性肝衰竭合并严重骨髓抑制1例报告

DOI: 10.3969/j.issn.1001-5256.2019.09.034

深圳市第三人民医院肝病医学中心

基金项目:

深圳市第三人民医院与中国人民解放军第三○二医院王福生院士团队合作项目(SZSM201612014)；

详细信息

中图分类号: R575.3;R551.3
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出版历程
- 出版日期: 2019-09-20

Acute-on-chronic liver failure with severe bone marrow suppression: A case report

Hepatology Medical Center, Shenzhen Third People's Hospital

Research funding:

摘要

摘要: <正>1病例资料患者女性,28岁,因发现HBsA g阳性10余年,上腹痛4 d,身目黄染1 d于2019年1月10日入院诊治。10余年前患者体检发现HBsAg阳性,当时肝功能正常,患者无特殊不适,未予特殊处理;患者起病前长期熬夜,劳累,4 d前开始出现上腹痛,剑突下为主,伴腹胀,恶心,无呕吐,无畏寒、发热;无胸闷、气促;
- 慢加急性肝功能衰竭 /
- 骨髓疾病 /
- 细菌感染
- acute-on-chronic liver failure /
- bone marrow diseases /
- bacterial infections

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参考文献(17)

[1] Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure (2018) [J]. J Clin Hepatol, 2019, 35 (1) :38-44. (in Chinese) 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南 (2018年版) [J].临床肝胆病杂志, 2019, 35 (1) :38-44.

[2] ZHOU GL, XIE ZJ, LIU CW, et al. Effect of artificial liver plasma filtration dialysis on patients with advanced liver failure[J].Jiangxi Med, 2013, 48 (12) :1138-1139. (in Chinese) 周观林, 谢志军, 刘春文, 等.人工肝血浆滤过透析法对肝衰竭晚期患者的作用[J].江西医药, 2013, 48 (12) :1138-1139.

[3] SOOD MM, SHAFER LA, HO J, et al. Early reversible acute kidneyinjury is associated with improved survival in septic shock[J]. J Crit Care, 2014, 29 (5) :711-717.

[4] NIE QH, ZHU T. New progress in the treatment of complications of liver failure[J]. Infect Dis Info, 2014, 27 (4) :204-208. (in Chinese) 聂青和, 朱婷.肝衰竭并发症治疗新进展[J].传染病信息, 2014, 27 (4) :204-208.

[5] XIANG FM, HU XH, RAO KH, et al. Comparative analysis of clinical significance of procalcitonin and white blood cell count in infectious diseases[J]. Jiangxi Med, 2014, 49 (12) :1565-1566. (in Chinese) 项凤梅, 胡小花, 饶珂寒, 等.降钙素原与白细胞计数在感染性疾病的临床意义比较分析[J].江西医药, 2014, 49 (12) :1565-1566.

[6] ALBA GA, TRUONG QA, GAGGIN HK, et al. Diagnostic and prognostic utility of procalcitonin in patients presenting to the emergency department with dyspne[J]. Am J Med, 2016, 129 (1) :96-104.

[7] TAYLOR R, JONES A, KELLY S, et al. A review of the value of procalcitonin as a marker of infection[J]. Cureus, 2017, 9 (4) :1148.

[8] YANG Y, LI L, QU C, et al. Diagnostic accuracy of serum procalcitonin for spontaneous bacterial peritonitis due to endstage liver disease:A meta-analysis[J]. Medicine (Baltimore) , 2015, 94 (49) :2077.

[9] MALLET M, HAQ M, TRIPON S, et al. Elevated procalcitonin is associated with bacterial infection during acute liver failure only when unrelated to acetaminophen intoxication[J]. Eur J Gastroenterol Hepatol, 2017, 29 (7) :811-816.

[10] BAJAJ JS, ZADVORNOVA Y, HEUMAN DM, et al. Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites[J]. Am J Gastroenterol, 2009, 104 (5) :1130-1134.

[11] BAJAJ JS, RATLIFF SM, HEUMAN DM, et al. Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis[J]. Aliment Pharmacol Ther, 2012, 36 (9) :866-874.

[12] GAIA S, SMEDILE A, OMEDP, et al. Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilizationin patients with end stage liver disease[J]. J Hepatol, 2006, 45 (1) :13-19.

[13] SPAHR L, LAMBERT JF, RUBBIA-BRANDT L, et al. Granulocyte-colony stimulating factor induces proliferation of hepatic progenitors in alcoholic steatohepatitis:A randomized trial[J]. Hepatology, 2008, 48 (1) :221-229.

[14] YANG HZ, ZHENG NN, HU JH. Immunomodulatory effects of recombinant human granulocyte colony-stimulating factor and its application in liver failure[J]. Chin J Hepatol, 2013, 21 (9) :718-720. (in Chinese) 杨昊臻, 郑楠楠, 胡瑾华.重组人粒细胞集落刺激因子的免疫调节作用及其在肝衰竭中的应用[J].中华肝脏病杂志, 2013, 21 (9) :718-720.

[15] HUANG K, YU JF, WU LL, et al. Meta-analysis of the efficacy of granulocyte colony-stimulating factor in the treatment of chronic acute liver failure[J]. Infect Dis Info, 2018, 31 (5) :439-442. (in Chinese) 黄坤, 于久飞, 吴丽丽, 等.粒细胞集落刺激因子治疗慢加急性肝衰竭疗效荟萃分析[J].传染病信息, 2018, 31 (5) :439-442.

[16] JIAO JZ, LI XY, HE SQ, et al. Clinical analysis of 110 cases of liver disease complicated with hematological diseases[J]. Med J Natl Defend Forces Northwest China, 2010, 31 (1) :57-58. (in Chinese) 焦建中, 李晓云, 何士强, 等.肝病合并血液系统疾病110例临床分析[J].西北国防医学杂志, 2010, 31 (1) :57-58.

[17] DING QY, YIN GQ, YU HY, et al. Report of 3 cases of viral hepatitis-associated myelosuppression[J]. Shandong Med, 2007, 47 (32) :18. (in Chinese) 丁巧云, 殷国庆, 俞海英, 等, 病毒性肝炎相关性骨髓抑制3例报告[J].山东医药, 2007, 47 (32) :18.

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