Epidemiology of nonalcoholic fatty liver disease and related risk factors
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摘要: 非酒精性脂肪性肝病(NAFLD)最早的流行病学研究主要集中在西方国家,但越来越多的研究表明NAFLD在亚太地区非常普遍,并且亚太和西方国家之间在表型上可能存在很大区别。肥胖、血脂异常、2型糖尿病已证明是NAFLD发生的危险因素。同时西方国家已经描述了NAFLD的许多其他危险因素(如甲状腺功能减退症、多囊卵巢综合征、阻塞性睡眠呼吸暂停、垂体和性腺机能减退),但这些因素尚未在亚太地区发现其与NAFLD有关。主要讨论了亚太地区特别是中国NAFLD的流行病学和危险因素。Abstract: The earliest epidemiological studies of nonalcoholic fatty liver disease ( NAFLD) were mainly conducted in Western countries, while more and more studies have shown that NAFLD is very common in the Asia-Pacific region and that there may be great differences in phenotype between the Asia-Pacific and Western countries. Obesity, dyslipidemia, and type 2 diabetes have been shown to be the risk factors for the development of NAFLD. Meanwhile, Western countries have described many other risk factors for NAFLD, such as hypothyroidism, polycystic ovary syndrome, obstructive sleep apnea syndrome, hypopituitarism, and hypogonadism, but these factors have not yet been found to be associated with NAFLD in the Asia-Pacific region.
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Key words:
- fatty liver /
- epidemiology /
- risk factors
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