TNFα/NF-κB信号通路调控非酒精性脂肪性肝病的研究现状

孙婷婷; 李京涛; 魏海梁; 闫曙光; 李倩; 郭英君; 常占杰

doi:10.3969/j.issn.1001-5256.2019.09.047

TNFα/NF-κB信号通路调控非酒精性脂肪性肝病的研究现状

DOI: 10.3969/j.issn.1001-5256.2019.09.047

1. 陕西中医药大学
2. 陕西中医药大学附属医院
3. 宁夏回族自治区人民医院

基金项目:

国家自然科学基金(81603612)；陕西省科技厅科研基金(2016SF-234,2018KJXX-093)；陕西省教育厅基金(16JK1212)；陕西省中管局基金(15-JC008)；宁夏回族自治区自然科学基金(NZ17278)；陕西中医药大学学科创新团队建设项目(2019-YL05)；银川市2017年科技攻关项目；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2019-04-09
- 出版日期: 2019-09-20

Research advances in the role of the TNF-α/NF-κB signaling pathway in the regulation of nonalcoholic fatty liver disease

Shaanxi University of Chinese Medicine

Research funding:

摘要

摘要: TNFα可诱导肝脏炎症反应,促进肝细胞变性、坏死。核因子-κB（NF-κB）作为重要的转录调控因子,在非酒精性脂肪性肝病（NAFLD）中起着促进肝脏脂肪变性的重要作用。TNFα/NF-κB信号通路在各种信号刺激的条件下促进了NAFLD的发展。主要讨论了TNFα/NF-κB信号通路在NAFLD中的作用机制,旨在为NAFLD患者提供新的治疗靶点。
- 非酒精性脂肪性肝病 /
- 肿瘤坏死因子α /
- NF-κB
Abstract: Tumor necrosis factor-α ( TNF-α) can induce liver inflammation and promote hepatocyte degeneration and necrosis, and as an important transcription regulator, nuclear factor-κB ( NF-κB) can promote hepatic steatosis in nonalcoholic fatty liver disease ( NAFLD) .The TNF-α/NF-κB signaling pathway promotes the development of NAFLD under the stimulation of various signals. This article discusses the mechanism of action of the TNF-α/NF-κB signaling pathway in NAFLD, so as to provide new therapeutic targets for patients with NAFLD.
- nonalcoholic fatty liver disease /
- tumor necrosis factor-alpha /
- NF-kappa B

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参考文献(33)

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