程序性死亡蛋白-1抑制剂致肝损伤研究进展

闫琪; 宋立莎; 辛桂杰

doi:10.3969/j.issn.1001-5256.2019.09.051

程序性死亡蛋白-1抑制剂致肝损伤研究进展

DOI: 10.3969/j.issn.1001-5256.2019.09.051

1. 吉林大学第一医院肝胆胰内科
2. 吉林大学第一医院二部急救科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-03-28
- 出版日期: 2019-09-20

Research advances in liver injury induced by programmed death protein-1 inhibitors

Department of Hepatology, The First Hospital of Jilin University

摘要

摘要: 随着程序性死亡蛋白-1抑制剂在肿瘤治疗中的应用,其带来的副反应——免疫相关不良反应（irAEs）也在全身发生,然而对irAEs中的肝损伤研究较少。主要阐述了程序性死亡蛋白-1抑制剂致肝损伤的分子机制、疾病分级、发病率、发病时间、血清学、组织学、影像学、生物标志物方面的特征以及治疗手段,进而全面认识irAEs中的肝损伤。认为其所致的肝损伤发病率虽低,但高级别肝损伤危险度较高,医务人员应引起注意,对其尽早识别并正确应对。
- 药物性肝损伤 /
- 程序性死亡蛋白-1抑制剂
Abstract: With the application of programmed cell death-1 ( PD-1) inhibitors in tumor treatment, related side effects and immune-related adverse events ( irAEs) are observed in the whole body; however, there are few studies on liver injury in irAEs. This article elaborates on the features of liver injury induced by PD-1 inhibitors from the aspects of molecular mechanism, disease grade, incidence rate, onset time, serology, histology, imaging, and biomarkers and related treatment methods, so as to provide a comprehensive understanding of liver injury in irAEs. It is believed that although there is a low incidence rate of liver injury caused by PD-1 inhibitors, high-grade liver injury has a high level of risk. Such liver injury should be taken seriously by the medical staff, and early identification and proper treatment should be performed.
- drug-induced liver injury /
- programmed cell death-1 inhibitors

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参考文献(30)

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