肝类器官研究及应用进展

王利; 丘倚灵; 王建设

doi:10.3969/j.issn.1001-5256.2019.10.047

肝类器官研究及应用进展

DOI: 10.3969/j.issn.1001-5256.2019.10.047

1. 复旦大学附属儿科医院肝病科
2. 复旦大学附属金山医院儿科

基金项目:

国家自然科学基金面上项目(81570468,81873543)；

详细信息

中图分类号: R575
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- 文章访问数: 1645
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- 被引次数: 0
出版历程
- 收稿日期: 2019-05-22
- 出版日期: 2019-10-20

Advances in research and application of liver organoids

Department of Hepatology,Children's Hospital of Fudan University

Research funding:

摘要

摘要: 经典的肝脏研究模型因其无法长期维持肝细胞极性结构,或遗传代谢背景与正常人肝细胞有较大差别,对肝细胞生理功能及相关疾病机制研究存在限制。新近建立的肝类器官培养技术,可通过重编程的诱导多能干细胞或肝活检组织体外培养获得具有部分肝组织结构的肝类器官,并长期维持可扩增性和遗传稳定性,有望成为疾病建模、药物筛选及细胞治疗的有力工具。主要对肝类器官的研究现状及应用前景进行综述。
- 类器官 /
- 肝 /
- 多能干细胞
Abstract: Liver diseases significantly affect human health. Classic research models cannot maintain hepatocyte polarity for a long time and have a different genetic background from normal human hepatocytes,which limits the research on the physiological functions of hepatocytes and the mechanisms of related diseases. The latest liver organoid technology can obtain liver organoids with partial liver structure by reprogrammed induced pluripotent stem cells or in vitro culture of liver biopsy tissue and maintain long-term proliferation and genetic stability,and therefore,it is expected to become a powerful tool for disease modelling,drug screening,and cell therapy. This article mainly reviews the research and application of liver organoids in recent years.
- organoids /
- liver /
- multipotent stem cells

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参考文献(35)

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