NOD样受体蛋白3炎性体在肝脏疾病发生发展中的作用

叶倩伶; 毛德文; 王明刚; 王娜

doi:10.3969/j.issn.1001-5256.2019.10.048

NOD样受体蛋白3炎性体在肝脏疾病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2019.10.048

1. 广西中医药大学
2. 广西中医药大学第一附属医院

基金项目:

国家自然科学基金项目(81774236,81704021,81760844)；广西自然科学基金(2017GXNSFBA198200,2018GXNSFAA281047);广西自然科学基金创新研究团队项目(2018GXNSFGA281002)；广西高校中青年教师基础能力提升项目(KY2016YB208)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-05-20
- 出版日期: 2019-10-20

Role of NLRP3 inflammasome in the development and progression of liver diseases

Guangxi University of Chinese Medicine

Research funding:

摘要

摘要: 炎性体诱发的免疫瀑布是近年研究的热点话题,作为研究得较为透彻的NOD样受体蛋白3(NLRP3)炎性体,其在肝脏疾病发生发展中扮演的角色日益受到重视。以病毒性肝炎、肝纤维化、非酒精性脂肪性肝病、肝衰竭、肝癌为切入点,深入剖析目前NLRP3炎性体在疾病中的作用特点和调节机制。围绕NLRP3炎性体形成靶向治疗手段,以适应性调控炎性体触发的免疫反应,进而为防治肝脏疾病提供思路。
- 肝疾病 /
- NLR家族,热蛋白结构域包含蛋白3 /
- 炎性体
Abstract: Immune cascade due to inflammasome has become a research hotspot in recent years,and the role of NLRP3 inflammasome in the development and progression of liver diseases has attracted more and more attention. This article analyzes the action characteristics and regulatory mechanism of NLRP3 inflammasome in liver diseases,such as viral hepatitis,liver fibrosis,nonalcoholic fatty liver disease,liver failure,and liver cancer,and establishes targeted therapy based on NLRP3 inflammasome to regulate immune response triggered by inflammasome,in order to provide new ideas for the prevention and treatment of liver diseases.
- liver diseases /
- NLR family,pyrin domain-containing 3 protein /
- inflammasomes

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