肠道微生态在肝内胆汁淤积中的作用机制

黄倩; 张海博; 李京涛; 魏海梁; 闫曙光; 惠毅; 常占杰

doi:10.3969/j.issn.1001-5256.2019.10.050

肠道微生态在肝内胆汁淤积中的作用机制

DOI: 10.3969/j.issn.1001-5256.2019.10.050

1. 陕西中医药大学
2. 大连医科大学医学科学研究院
3. 陕西中医药大学附属医院肝病科

基金项目:

国家自然科学基金(81603612)；陕西省科技厅科研基金(2014K11-02-04-06,2016SF-234,2018KJXX-093)；陕西省中医药管理局科研基金(15-JC009)；国家大学生创新创业训练计划项目(201810716023)；陕西省大学生创新创业训练计划项目(201831023)；陕西中医药大学学科创新团队建设项目(2019-YL05)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-05-15
- 出版日期: 2019-10-20

Research advances in the mechanism of action of intestinal microecology in intrahepatic cholestasis

Shaanxi University of Chinese Medicine

Research funding:

摘要

摘要: 肝内胆汁淤积是由遗传、免疫、炎症、结石、肿瘤等多种原因引起的胆汁生成、分泌、排泄功能障碍,不能正常排入十二指肠而逆流入血,引起一系列器质性损害、代谢失调和功能紊乱的临床疾病。近年来,随着临床和基础研究的不断深入,揭示出肠道微生态在肝脏疾病发生发展中扮演着重要角色。综述了肠道微生态及炎症因子在肝内胆汁淤积中的作用机制,探究益生菌在调节肠道菌群稳态,改善肠道微环境等方面进展,为临床治疗、科研研究和药物研发等提供借鉴。
- 胆汁淤积,肝内 /
- 胃肠道微生物组 /
- 治疗学
Abstract: Intrahepatic cholestasis(IHC) is a dysfunction of bile production,secretion,and excretion caused by various factors including genetics,immunity,inflammation,stones,and tumors,and therefore,the bile is not normally discharged into the duodenum and reversely flows into blood,which causes a series of clinical diseases with organic damage,metabolic disorders,and dysfunction. In recent years,with the deepening of clinical and basic research,intestinal microecology is found to play an important role in the development and progression of liver diseases. This article reviews the mechanism of action of intestinal microecology and inflammatory factors in intrahepatic cholestasis and explores the research advances in the role of probiotics in regulating intestinal flora stability and improving intestinal microenvironment,so as to provide a basis for clinical treatment,scientific research,and drug research and development.
- cholestasis,intrahepatic /
- gastrointestinal microbiome /
- therapeutics

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