原发性胆汁性胆管炎的熊去氧胆酸生化应答预测及中西医结合治疗

王晓静; 刘尧; 王宪波

doi:10.3969/j.issn.1001-5256.2020.01.004

原发性胆汁性胆管炎的熊去氧胆酸生化应答预测及中西医结合治疗

DOI: 10.3969/j.issn.1001-5256.2020.01.004

首都医科大学附属北京地坛医院中西医结合中心

基金项目:

国家中医药管理局区域中医肝病诊疗中心建设项目；国家“十三五”科技重大专项(2018ZX10723203)；首都卫生发展科研专项(2018-1-2172)；北京市科学技术委员会资助(Z191100006619033)；国家重大疑难疾病中西医临床协作试点项目；

详细信息

中图分类号: R575.7
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出版历程
- 收稿日期: 2019-12-20
- 出版日期: 2020-01-20

Biochemical response and integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis

Department of Integrative Medicine,Beijing Ditan Hospital,Capital Medical University

Research funding:

摘要

摘要: 原发性胆汁性胆管炎(PBC)是免疫介导的慢性进展性的肝内胆汁淤积性疾病,熊去氧胆酸(UDCA)的治疗可明显改善PBC患者的预后,但仍存在一定的UDCA应答不佳的人群,是目前导致疾病进展的主要危险因素。多个基于生化应答的评估模型及评分系统已应用于临床用于筛选应答不佳者。中西医结合治疗PBC在临床上显示了很好的前景,在改善PBC患者症状、肝脏生化及纤维化指标,提高生化应答率等方面有一定优势,但在临床研究设计、疗效判定等方面尚需要进一步完善。
- 原发性胆汁性胆管炎 /
- 生化学应答 /
- 中西医结合疗法
Abstract: Primary biliary cholangitis(PBC) is an immune-mediated chronic and progressive intrahepatic cholestasis disease. Treatment with ursodeoxycholic acid(UDCA) can significantly improve the prognosis of patients with PBC,but some patients still have poor response to UDCA,which is the main risk factor for disease progression. Several evaluation models and scoring systems based on biochemical response have been applied to screen out patients with poor response in clinical practice. Integrated traditional Chinese and Western medicine therapy for PBC has certain advantages in improving the symptoms,liver biochemistry,fibrosis indices,and biochemical response rate of PBC patients and thus holds promise for clinical application; however,further improvement is needed for experimental design and efficacy evaluation.
- primary biliary cholangitis /
- biochemical response /
- TCM WM therapy

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参考文献(40)

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