A case of primary hepatic high-grade neuroendocrine carcinoma
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摘要: <正>1病例资料患者男性,61岁,因"腹痛、乏力7 d"于2019年4月30日入本院,无恶心、呕吐,既往体健。入院查体:皮肤巩膜轻度黄染,右上腹部压痛明显,无其他阳性体征。入院血生化检查:TBil 31. 8μmol/L,DBil 9. 3μmol/L,IBil 22. 5μmol/L,ALT 135. 9 U/L,AST 163. 3 U/L,GGT 115. 1 U/L,余未见异常。肿瘤标志物:AFP3. 12 ng/ml,细胞角蛋白19片段20. 47 ng/ml,神经元特异性烯醇化酶(neuron-specific enolase,NSE) 176. 25 ng/ml。实验室指
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Key words:
- neuroendocrine neoplasms /
- liver neoplasms /
- diagrosis /
- therapeutics
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[1] ZHAO J,YANG B,XU C,et al. Study on clinicopathologic grading system and prognosis of primary hepatic neuroendocrine neoplasms[J]. Chin J Pathol,2012,41(2):102-106.(in Chinese)赵婧,杨博,徐晨,等.肝脏原发性神经内分泌肿瘤临床病理分类及预后分析[J].中华病理学杂志,2012,41(2):102-106. [2] CAMARGOS,VIVEIROS MDE M,CORRA NETO IJ,et al.Primary hepatic carcinoid tumor:Case report and literature review[J]. Einstein,2014,12(4):505-508. [3] QUARTEY B. Primary hepatic neuroendocrine tumor:What do we know now?[J]. World J Oncol,2011,2(5):209-216. [4] EDMONDSON HA. Tumors of the liver and intrahepatic bile ducts:Atlas of tumor pathology,sect 7,fasc,25[M]. Washington DC:Armed Forces Institute of Pathology,1958:105-111. [5] MENG XF,PAN YW,WANG ZB,et al. Primary hepatic neuroendocrine tumor case with a preoperative course of 26 years:A case report and literature review[J]. World J Gastroenterol,2018,24(24):2640-2646. [6] HU X,HUANG Z,ZHANG Y,et al. Primary hepatic neuroendocrine tumor:Report of one case[J]. Transl Gastroenterol Hepatol,2016,1:82. [7] GAO WH,XIANG XX. Primary hepatic neuroendocrine neoplasm:A report of 2 cases and literature review[J]. J Clin Hepatol,2017,33(6):1149-1151.(in Chinese)高伟华,向晓星.原发性肝脏神经内分泌肿2例报告并文献复习[J].临床肝胆病杂志,2017,33(6):1149-1151. [8] PILICHOWSKA M,KIMURA N,OUCHI A,et al. Primary hepatic carcinoid and neuroendocrine carcinoma:Clinicopathological and immunohistochemical study of five cases[J].Pathol Int,1999,49(4):318-324. [9] DALA R,SHOOSMITH J,LILENBAUM R,et al. Primary hepatic neuroendocrine carcinoma:An underdiagnosed entity[J]. Ann Diagn Pathol,2006,10(1):0-31. [10] HSUEH C,TAN XD,GONZALEZ-CRUSSI F. Primary hepatic neuroendocrine carcinoma in a child morphologic,immunocytochemical, and molecular biologic studies[J]. Cancer(Philadelphia),1993,71(8):2660-2665. [11] YANG K,CHENG YS,YANG JJ,et al. Primary hepatic neuroendocrine tumor with multiple liver metastases:A case report with review of the literature[J]. World J Gastroenterol,2015,21(10):3132-3138. [12] KAYA G,PASCHE C,OSTERHELD MC,et al. Primary neuroendocrine carcinoma of the liver:An autopsy case[J]. Pathology International,2001,51(11):874-878. [13] AKAHORI T,SHO M,TANAKA T,et al. Significant efficacy of new transcatheter arterial chemoembolization technique for hepatic metastases of pancreatic neuroendocrine tumors[J].Anticancer Res,2013,33(8):3355-3358. [14] Expert Group of Chinese Consensus on Pathological Diagnosis of Gastroenteropancreatic Neuroendocrine Neoplasm. Chinese consensus on pathological diagnosis of gastroenteropancreatic neuroendocrine neoplasm(2013)[J]. Chin J Pathol,2013,42(10):691-694.(in Chinese)中国胃肠胰神经内分泌肿瘤病理诊断共识专家组.中国胃肠胰神经内分泌肿瘤病理诊断共识(2013年版)[J].中华病理学杂志,2013,42(10):691-694. [15] DOMNGUEZ N,ESTVEZ-HERRERA J,PARDO MR,et al.The functional role of chromogranins in exocytosis[J]. J Mol Neurosci,2012,48(2):317-322. [16] BOSMAN FT,CARNEIRO,HRUBAN RH,et al. WHO classification of tumors of the digestive system[M]. 4th ed,World Health Organization,2010. [17] WEISS VL,KIERNAN C,WRIGHT J,et al. Fine-needle aspiration-based grading of pancreatic neuroendocrine neoplasms using Ki-67:Is accurate who grading possible on cytologic material?[J]. J Am Soc Cytopathol,2018,7(3):154-459. [18] KNOX CD,ANDERSON CD,LAMPS LW,et al. Long-term survival after resection for primary hepatic carcinoid tumor[J].Ann Surg Oncol,2003,10(10):1171-1175. [19] IWAO M,NAKAMUTA M,ENJOJI M,et al. Primary hepatic carcinoid tumor:Case report and review of 53 cases[J]. Med Sci Monit,2001,7(4):746-750. [20] DONG X,CARR BI. Hepatic artery chemoembolization for the treatment of liver metastases from neuroendocrine tumors:A long—term follow-up in 123 patients[J]. Med Oncol,2011,28(Suppl):s286-s290. [21] RAJ N,VALENTINO E,CAPANU M,et al. Treatment response and outcomes of grade 3 pancreatic neuroendocrine neoplasms based on morphology:Well differentiated versus poorly differentiated[J]. Pancreas,2017,46(3):296-301. [22] PARK CH,CHUNG JW,JANG SJ,et al. Clinical features and outcomes of primary hepatic neuroendocrine carcinomas[J].J Gastroenterol Hepatol,2012,27(8):1306-1311 [23] VLADIMIR N,ELECTRON K. Management options for advanced low or intermediate grade gastroenteropancreatic neuroendocrine tumors:Review of recent literature[J]. Int J Surg Oncol,2017,2017:1-14.
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