雌激素受体α基因多态性与乙型肝炎肝硬化的关系

程娜; 杨京

doi:10.3969/j.issn.1001-5256.2020.01.044

雌激素受体α基因多态性与乙型肝炎肝硬化的关系

DOI: 10.3969/j.issn.1001-5256.2020.01.044

程娜,
杨京

贵州医科大学附属医院感染科

详细信息

中图分类号: R512.62;R575.2
计量
- 文章访问数: 1010
- HTML全文浏览量: 55
- PDF下载量: 182
- 被引次数: 0
出版历程
- 收稿日期: 2019-08-21
- 出版日期: 2020-01-20

Association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis

Cheng Na,
Yang Jing

Department of Infectious Diseases,Guizhou Medical University

摘要

摘要: 目前,乙型肝炎肝硬化对公众的健康及国家的发展仍有重大的影响。乙型肝炎肝硬化的发生发展与雌激素有关,雌激素通过与雌激素受体结合发挥作用,雌激素受体的表达和功能状态受雌激素受体基因多态性的影响。介绍了雌激素与雌激素受体α基因的结构和生物学特征,以及分别与乙型肝炎肝硬化发病的相关性,指出雌激素的异常表达可能与乙型肝炎肝硬化的发生发展有关。然而可能由于研究的基因位点、环境、地点等不同,最终得出的雌激素受体α基因多态性与乙型肝炎肝硬化相关性的结果不完全一致。
- 雌激素受体α /
- 多态现象,遗传 /
- 乙型肝炎 /
- 肝硬化
Abstract: At present,hepatitis B cirrhosis still has a major impact on public health and national development. The development and progression of hepatitis B cirrhosis is associated with estrogen. Estrogen acts by binding to estrogen receptors,and the expression and functional status of estrogen receptors are affected by estrogen receptor gene polymorphisms. This article mainly introduces the structure and biological characteristics of estrogen and estrogen receptor α gene and their association with the pathogenesis of hepatitis B cirrhosis,and it is pointed out that the abnormal expression of estrogen may be associated with the development and progression of hepatitis B cirrhosis. However,due to the differences in genetic loci,environment,and location between studies,the results of the association of estrogen receptor α gene polymorphisms with hepatitis B cirrhosis may not be completely consistent.
- estrogen receptor alpha /
- polymorphism,genetic /
- hepatitis B /
- liver cirrhosis

HTML全文

参考文献(31)

[1] European association for the study of the liver. EASL clinical practice guidlines:Management of chronic hepatitis B[J].Hepatology,2009,50(2):227-242.

[2] JIN CT,GUO LW,LIANG WF. Research progress on non-invasive serum markers for liver fibrosis assessment in patients with chronic hepatitis B[J/CD]. Chin J Exp Clin Infect Dis(Electronic Edition),2018,12(1):11-14.(in Chinese)金彩婷，郭利伟，梁伟峰．慢性乙型病毒性肝炎肝纤维化无创性血清诊断指标研究进展[J/CD]．中华实验和临床感染病杂志(电子版)，2018,12(1):11-14.

[3] LIANG P,ZHENG RQ. Guidelines for clinical application of two-dimensional shear wave elastography in assessment of liver fibrosis in chronic hepatitis B[J]. J Clin Hepatol,2018,34(2):255-261.(in Chinese)梁萍，郑荣琴．二维剪切波弹性成像评估慢性乙型肝炎肝纤维化临床应用指南[J]．临床肝胆病杂志，2018,34(2):255-261.

[4] ZHAO F,ZHAO J,CHEN J,et al. Comparison of diagnostic value of Fibroscan and ARFI on liver fibrosis in patients with chronic hepatitis B[J/CD]. Chin J Liver Dis(Electronic Version),2019,11(2):71-75.(in Chinese)赵帆，赵娟，陈静，等．Fibroscan和ARFI对慢性乙型肝炎肝纤维化诊断价值比较[J/CD]．中国肝脏病杂志(电子版)，2019,11(2):71-75.

[5] KUMAR R,ZAKHAROV MN,KHAN SH,et al. The dynamic structure of the estrogen receptor[J]. J Amino Acids,2011,2011:812540.

[6] DONG X,FU P. Research progress on the relationship between estrogen receptor gene polymorphism and gynecological disease[J]. Chin J Birth health Heredity,2011,19(11):1-4.(in Chinese)董迅，傅萍．雌激素受体基因多态性与妇科疾病关系研究进展[J]．中国优生与遗传杂志，2011,19(11):1-4.

[7] LUO XL,TAN WT,ZHOU Y,et al. Expression and clinical significance of ERαand ERβin HBV-associated hepatocellular carcinoma[J]. J Third Milit Med Univ,2014,36(6):564-567.(in Chinese)罗晓丽，谭文婷，周媛，等．ERα及ERβ在HBV相关肝细胞癌中的表达及临床意义[J]．第三军医大学学报，2014,36(6):564-567.

[8] LUO XL. Expression and significance of estrogen receptorαand its variants in HBV-related liver diseases[D]. Chongqing:Third Military Medical University,2014.(in Chinese)罗晓丽．雌激素受体α及其变异体在HBV相关肝病中的表达及意义[D]．重庆:第三军医大学，2014.

[9] ZHU XP. Study on the relationship between IL-10 gene polymorphism and Behcet disease and Vogt-small willow field syndrome[D]. Fujian:Fujian Medical University,2014.(in Chinese)朱雪平．白介素10基因多态性与Behcet病及Vogt-小柳原田综合征相关性研究[D]．福州:福建医科大学，2014.

[10] BARKUR SS. SNP alleles in human disease and evolution[J].J Hum Genet,2002,47(11):561-566.

[11] CORREA-RODRGUEZ M,SCHMIDT-RIOVALLE J,GONZLEZ-JIMNEZ E,et al. Estrogen receptor 1(ESR1)gene polymorphisms and obesity phenotypes in a population of young adults[J]. Clin Nurs Res,2017,27(8):936-949.

[12] SALIMI S,FARAJIAN-MASHHADI F,TABATABAEI E,et al.Estrogen receptor alpha XbaI GG genotype was associated with severe preeclampsia[J]. Clin Exp Hypertens,2017,39(3):220-224.

[13] HAN Z,ZHANG L,ZHU R,et al. Relationship of oestrogen receptor alpha gene polymorphisms with risk for benign prostatic hyperplasia and prostate cancer in Chinese men[J].Medicine,2017,96(13):e6473.

[14] LEE YH,SONG GG. Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer’s disease:A meta-analysis[J]. Genet Mol Res,2015,14(3):9361-9369.

[15] XU GH,XU ZQ,HE J,et al. Relationship between ERα-29polymorphism and primary liver cancer associated with HBV infection[J]. Chin J Gerontol,2018,38(2):371-373.(in Chinese)徐国辉，徐宗全，何均，等．ERα-29位多态性与HBV感染相关原发性肝癌的关系[J]．中国老年学杂志，2018,38(2):371-373.

[16] WEN B,YUAN H,XIA Z,et al. Clinical analysis of occurring model and correlated factors of hepatitis B cirrhosis in 502 patients[J]. J Mod Med Health,2010,26(15):2263-2264.(in Chinese)文彬，袁虹，夏章，等．乙型肝炎肝硬化患者502例的发生模式及相关因素分析[J]．现代医药卫生，2010,26(15):2263-2264.

[17] ABAKAR MAA,KAFI SK,AHMADABAKUR EH,et al. Association of age and gender with development of liver cirrhosis among hepatitis B virus-infected individuals in sudan[J].World J Pharm Res,2019,8(5):550-558.

[18] LEE YH,SONG JY,KIM KS,et al. Estrogen deficiency potentiates thioacetamide-induced hepatic fibrosis in spraguedawley rats[J]. Int J Mol Sci,2019,20(15):3709.

[19] SINCLAIR M,GOW PJ,ANGUS PW,et al. High circulating oestrone and low testosterone correlate with adverse clinical outcomes in men with advanced liver disease[J]. Liver Int,2016,36(11):1619-1627.

[20] PEREIRA GB,BARNEY J. Serum estradiol concentrations in male subjects with cirrhosis and critical illness[J]. Am J Respir Crit Care Med,2019,199:a1690.

[21] XIONG M. Analysis of non-traditional risk factors for hepatic fibrosis in patients with chronic hepatitis B:A prospective cohort study based on transient elastic imaging[D]. Guangzhou:Southern Medical University,2019.(in Chinese)熊鸣．慢性乙型肝炎患者肝纤维化的非传统危险因素分析—基于瞬时弹性成像的一项前瞻性队列研究[D]．广州:南方医科大学，2019.

[22] ZHANG B,WU ZY. Estrogen derivatives:Novel therapeutic agents for liver cirrhosis and portal hypertension[J]. Eur J Gastroenterol Hepatol,2013,25(3):263-227.

[23] LANDER ES. 2018 William allan award:Discovering the genes for common disease:From families to populations[J]. Am J Hum Genet,2019,104(3):375-383.

[24] DENG G,ZHOU G,ZHAI Y,et al. Association of estrogen receptorαpolymorphisms with susceptibility to chronic hepatitis B virus infection[J]. Hepatology,2004,40(2):318-326.

[25] YAN ZH,TAN WT,DAN YJ,et al. Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population[J]. BMC Med Gent,2012,13(1):49.

[26] ZHOU N,LI WF,ZHANG XW. Analysis of the relationship between ERα-29 gene polymorphism and chronic HBV infection in Gansu[J]. J Fourth Milit Med Univ,2009,30(17):1603-1606.(in Chinese)周宁，李文凡，张兴旺．ERα-29位基因多态性与甘肃地区慢性HBV感染的相关性分析[J]．第四军医大学学报，2009,30(17):1603-1606.

[27] ZHANG KH. Multilocus gene polymorphism analysis and molecular prediction of hepatitis B liver cirrhosis risk[D]. Nanchang:Nanchang University,2009.(in Chinese)张焜和．多位点基因多态性分析与乙肝肝硬化风险的分子预测[D]．南昌:南昌大学，2009.

[28] LIU Y. Estrogen receptor gene polymorphism and genetic susceptibility to hepatitis B,liver cirrhosis and liver cancer[D].Nanning:Guangxi Medical University,2012.(in Chinese)刘岩．雌激素受体基因多态性与乙型肝炎、肝硬化、肝癌的遗传易感性研究[D]．南宁:广西医科大学，2012.

[29] LIU Y,LIU Y,HUANG X,et al. Association of PvuII and XbaI polymorphisms in estrogen receptor alpha gene with the risk of hepatitis B virus infection in the Guangxi Zhuang population[J]. Infect Genet Evol,2014,27:69-76.

[30] YAN ZH. Identification of IL-10/ESR1 r SNP gene associated with liver disease and its function in HBV-related liver disease[D]. Chongqing:Third military Medical University,2009.(in Chinese)晏泽辉．肝病关联基因IL-10/ESR1 r SNP的鉴定及其在HBV相关肝病中的功能研究[D]．重庆:第三军医大学，2009.

[31] YAN Z,TAN W,XU B,et al. A cis-acting regulatory variation of the estrogen receptorα(ESR1)gene is associated with hepatitis B virus-related liver cirrhosis[J]. Hum Mutat,2011,32(10):1128-1136.

施引文献

资源附件(0)

访问统计