非酒精性脂肪性肝病与抑郁症的关系

杨旭瑶; 余荻; 赵锦涵; 钏莉雪; 常江

doi:10.3969/j.issn.1001-5256.2020.01.048

非酒精性脂肪性肝病与抑郁症的关系

DOI: 10.3969/j.issn.1001-5256.2020.01.048

昆明医科大学第二附属医院消化内科

详细信息

中图分类号: R575.5;R749.4
计量
- 文章访问数: 1124
- HTML全文浏览量: 35
- PDF下载量: 304
- 被引次数: 0
出版历程
- 收稿日期: 2019-07-27
- 出版日期: 2020-01-20

Association between nonalcoholic fatty liver disease and depression

Department of Gastroenterology,The Second Hospital Affiliated to Kunming Medical University

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）已成为世界上最常见的慢性肝病之一。随着生物-心理-社会医学模式的发展,NAFLD患者的精神健康问题逐渐受到重视。近年来,NAFLD与精神性疾病,特别是抑郁症的相关研究越来越多,且证实二者存在明显的相关性。但二者相关性的共同病理生理机制仍不明确,孰因孰果及治疗方式亟待进一步研究。综述了NAFLD与抑郁症的关系、共同病理生理机制及治疗的研究进展。期望为两者关系更深层次的研究打下基础,有助于未来临床对这两种疾病进行联合预防和治疗。
- 非酒精性脂肪性肝病 /
- 抑郁症 /
- 治疗学
Abstract: At present,nonalcoholic fatty liver disease(NAFLD) has become one of the most common chronic liver diseases in the world.With the development of the bio-psycho-social medical model,the mental health problems of patients with NAFLD are gradually attracting more and more attention. In recent years,more and more studies have been conducted on the association between NAFLD and psychiatric diseases,especially depression. Studies have shown that there is a significant correlation between NAFLD and depression; however,the common pathophysiological mechanism of such correlation is still unclear and further studies are needed to determine their causal relationship and treatment. This article reviews the research advances in the association between NAFLD and depression,common pathophysiological mechanism,and treatment,so as to lay a foundation for further research on these two disease and help with their prevention and treatment in future clinical practice.
- non-alcoholic fatty liver disease /
- depressive disorder /
- therapeutics

HTML全文

参考文献(37)

[1] National Workshop on Fatty Liver and Alcoholic Liver Disease,Chinese Society of Hepatology,Chinese Medical Association Fatty Liver Expert Committee,Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease:A 2018 update[J]. J Clin Hepatol,2018,34(5):947-957.(in Chinese)中华医学会肝病学分会脂肪肝和酒精性肝病学组，中国医师协会脂肪性肝病专家委员会．非酒精性脂肪性肝病防治指南(2018年更新版)[J]．临床肝胆病杂志，2018,34(5):947-957.

[2] YOUNOSSI ZM,KOENIG AB,ABDELATIF D,et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology,2016,64(1):73-84.

[3] VARINTHRA P,LIU IY. Molecular basis for the association between depression and circadian rhythm[J]. Tzu Chi Med J,2019,31(2):67-72.

[4] VOINOV B,RICHIE WD,BAILEY RK. Depression and chronic diseases:It is time for a synergistic mental health and primary care approach[J]. Prim Care Companion CNS Disord,2013,15(2). pii:PCC. 12r01468.

[5] YOUSSEF NA,ABDELMALEK MF,BINKS M,et al. Associations of depression,anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease[J]. Liver Int,2013,33(7):1062-1070.

[6] ZELBER-SAGI S,TOKER S,ARMON G,et al. Elevated alanine aminotransferase independently predicts new onset of depression in employees undergoing health screening examinations[J]. Psychol Med,2013,43(12):2603-2613.

[7] KIM D,YOO ER,LI AA,et al. Depression is associated with non-alcoholic fatty liver disease among adults in the United States[J]. Aliment Pharmacol Ther,2019,50(5):590-598.

[8] JUNG JY,PARK SK,OH CM,et al. Non-alcoholic fatty liver disease and its association with depression in korean general population[J]. J Korean Med Sci,2019,34(30):e199.

[9] WEINSTEIN AA,KALLMAN PJ,STEPANOVA M,et al. Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C[J]. Psychosomatics,2011,52(2):127-132.

[10] TOMENO W,KAWASHIMA K,YONEDA M,et al. Non-alcoholic fatty liver disease comorbid with major depressive disorder:The pathological features and poor therapeutic efficacy[J]. J Gastroenterol Hepatol,2015,30(6):1009-1014.

[11] ELWING JE,LUSTMAN PJ,WANG HL,et al. Depression,anxiety, and nonalcoholic steatohepatitis[J]. Psychosom Med,2006,68(4):563-569.

[12] ZHU HP,GU YR,ZHANG GL,et al. Depression in patients with chronic hepatitis B and cirrhosis is closely associated with the severity of liver cirrhosis[J]. Exp Ther Med,2016,12(1):405-409.

[13] SINGH N,GAYOWSKI T,WAGENER MM,et al. Depression in patients with cirrhosis. Impact on outcome[J]. Dig Dis Sci,1997,42(7):1421-1427.

[14] MIRANDA DO,ANATRIELLO E,AZEVEDO LR,et al. Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy[J]. Cytokine,2018,104:72-77.

[15] CUI Y,WANG RN,WU JR,et al. Effect of water extract of spina date seed and albizzia julibrissin flower on hpa axis and inflammatory cytokines in anxious depression model rats[J]. J Jilin Univ(Med Edit),2019,45(3):539-545.(in Chinese)崔妍，王若男，吴九如，等．酸枣仁和合欢花水提取物对焦虑性抑郁症模型大鼠HPA轴及炎症因子的影响[J]．吉林大学学报(医学版)，2019,45(3):539-545.

[16] TAO YT,FAN JG. Psychological stress in nonalcoholic fatty liver disease[J]. J Pract Hepatol,2016,19(6):753-756.(in Chinese)陶叶婷，范建高．心理应激与非酒精性脂肪性肝病[J]．实用肝脏病杂志，2016,19(6):753-756.

[17] KIM KH,LEE MS. Pathogenesis of nonalcoholic steatohepatitis and hormone-based therapeutic approaches[J]. Front Endocrinol(Lausanne),2018,9:485.

[18] DINIZ BS,FISHER-HOCH S,MCCORMICK J. The association between insulin resistance,metabolic variables,and depressive symptoms in Mexican-American elderly:A population-based study[J]. Int J Geriatr Psychiatry,2018,33(2):e294-e299.

[19] LEE JH,PARK SK,RYOO JH,et al. The association between insulin resistance and depression in the Korean general population[J]. J Affect Disord,2017,208:553-559.

[20] WEBB M,DAVIES M,ASHRA N,et al. The association between depressive symptoms and insulin resistance,inflammation and adiposity in men and women[J]. PLo S One,2017,12(11):e0187448.

[21] SAFARI Z,GERARD P. The links between the gut microbiome and non-alcoholic fatty liver disease(NAFLD)[J]. Cell Mol Life Sci,2019,76(8):1541-1558.

[22] RAMAN M,AHMED I,GILLEVET PM,et al. Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease[J]. Clin Gastroenterol Hepatol,2013,11(7):868-875. e1-3.

[23] JIANG C,XIE C,LI F,et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease[J]. J Clin Invest,2015,125(1):386-402.

[24] WONG VW,TSE CH,LAM TT,et al. Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis--a longitudinal study[J]. PLo S One,2013,8(4):e62885.

[25] BAJAJ JS,RIDLON JM,HYLEMON PB,et al. Linkage of gut microbiome with cognition in hepatic encephalopathy[J]. Am J Physiol Gastrointest Liver Physiol,2012,302(1):g168-g175.

[26] VALLES-COLOMER M,FALONY G,DARZI Y,et al. The neuroactive potential of the human gut microbiota in quality of life and depression[J]. Nat Microbiol,2019,4(4):623-632.

[27] KELLY JR,BORRE Y,O’BRIEN C,et al. Transferring the blues:Depression-associated gut microbiota induces neurobehavioural changes in the rat[J]. J Psychiatr Res,2016,82:109-118.

[28] HUANG XY,LIU Y,ZHANG HY,et al. Progress on the relationship between chronic liver disease and depression[J/CD]. Chin J Liver Dis(Electr Version),2018,10(3):37-42.(in Chinese)黄鑫宇，刘玉，张华颖，等．慢性肝病与抑郁症研究进展[J/CD]．中国肝脏病杂志(电子版)，2018,10(3):37-42.

[29] DEL GRANDE DA SILVA G,WIENER CD,BARBOSA LP,et al. Pro-inflammatory cytokines and psychotherapy in depression:Results from a randomized clinical trial[J]. J Psychiatr Res,2016,75:57-64.

[30] ARVAND J,SHAFIABADI A,FALSAFINEJAD MR,et al. Depression in patients with chronic hepatitis B:An experience on individual solution-focused therapy[J]. Gastroenterol Hepatol Bed Bench,2012,5(3):166-168.

[31] SHEN JD,WEI Y,LI YJ,et al. Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress[J]. Metab Brain Dis,2017,32(4):1163-1172.

[32] YU YJ,TAN SY. Study on the effect of curcumin on nonalcoholic fatty liver disease[J]. Chin J Gastroenter Hepatol,2017,26(10):1107-1109.(in Chinese)俞媛洁，谭诗云．姜黄素对非酒精性脂肪性肝病的作用研究[J]．胃肠病学和肝病学杂志，2017,26(10):1107-1109.

[33] SCHWENGER K,BOLZON CM,LI C,et al. Non-alcoholic fatty liver disease and obesity:The role of the gut bacteria[J]. Eur J Nutr,2019,58(5):1771-1784.

[34] MANZHALII E,VIRCHENKO O,FALALYEYEVA T,et al. Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis:A pilot trial[J]. J Dig Dis,2017,18(12):698-703.

[35] MCKEAN J,NAUG H,NIKBAKHT E,et al. Probiotics and subclinical psychological symptoms in healthy participants:A systematic review and meta-analysis[J]. J Altern Complement Med,2017,23(4):249-258.

[36] SUN J,WANG F,HU X,et al. Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressivelike behavior in mice via the gut-brain axis[J]. J Agric Food Chem,2018,66(31):8415-8421.

[37] RUDZKI L,OSTROWAKA L,PAWLAK D,et al. Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression:A double-blind,randomized,placebo controlled study[J]. Psychoneuroendocrinology,2019,100:213-222.

施引文献

资源附件(0)

访问统计