急性胰腺炎与表观遗传调控机制

赵先林; 朱世峰; 康鸿鑫; 李娟; 唐文富; 万美华

doi:10.3969/j.issn.1001-5256.2020.01.054

急性胰腺炎与表观遗传调控机制

DOI: 10.3969/j.issn.1001-5256.2020.01.054

1. 四川大学华西医院中西医结合科
2. 浙江省立同德医院消化科

基金项目:

国家自然科学基金面上项目(81374042,81774160,81873203)；

详细信息

中图分类号: R576
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出版历程
- 出版日期: 2020-01-20

Acute pancreatitis and epigenetic regulation mechanisms

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

Research funding:

摘要

摘要:
急性胰腺炎是由酒精、胆结石、高脂及吸烟等多种生活环境因素诱导的胰腺局部及全身炎症反应疾病,具体发病机制仍不完全清楚。研究提示DNA甲基化、组蛋白修饰和非编码RNA等表观遗传调控机制在急性胰腺炎发生及进展中发挥重要作用。介绍了急性胰腺炎的常见诱因如酒精、胆结石、高脂、吸烟与表观遗传调控机制以及炎症反应与表观遗传调控机制,虽然急性胰腺炎的表观遗传学调控机制仍处于初步探索阶段,但仍为进一步理解急性胰腺炎的发生、发展及治疗提供了新的思路。
- 胰腺炎 /
- DNA甲基化 /
- 组蛋白修饰 /
- RNA,长链非编码
Abstract:
Acute pancreatitis is a local pancreatic and systemic inflammatory disease due to various living and environmental factors,such as alcohol,gallstones,high lipids,and smoking,and its pathogenesis remains unclear. Studies have shown that epigenetic regulation mechanisms,such as DNA methylation,histone modification,and non-coding RNA,play an important role in the development and progression of acute pancreatitis. This article introduces the association between the common causes of acute pancreatitis(including alcohol,gallstones,high lipids,and smoking) and epigenetic regulation mechanisms,as well as the association between inflammatory response and epigenetic regulation mechanisms. The preliminary exploration of epigenetic regulation mechanisms in acute pancreatitis provides new thoughts for further understanding the development,progression,and treatment of acute pancreatitis.
- pancreatitis /
- DNA methylation /
- histone code /
- RNA,long noncoding

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