中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

血清载脂蛋白A1和载脂蛋白B/A1比值对重型急性胰腺炎的预测价值

钟瑞 徐欢 彭燕 严永峰 蒋鑫 汪敏 付文广 汤小伟

钟瑞, 徐欢, 彭燕, 严永峰, 蒋鑫, 汪敏, 付文广, 汤小伟. 血清载脂蛋白A1和载脂蛋白B/A1比值对重型急性胰腺炎的预测价值[J]. 临床肝胆病杂志, 2020, 36(3): 631-635. DOI: 10.3969/j.issn.1001-5256.2020.03.032.
引用本文: 钟瑞, 徐欢, 彭燕, 严永峰, 蒋鑫, 汪敏, 付文广, 汤小伟. 血清载脂蛋白A1和载脂蛋白B/A1比值对重型急性胰腺炎的预测价值[J]. 临床肝胆病杂志, 2020, 36(3): 631-635. DOI: 10.3969/j.issn.1001-5256.2020.03.032.
Zhong Rui, Xu Huan, Peng Yan, Yan YongFeng, Jiang Xin, Wang Min, Fu WenGuang, Tang XiaoWei. Value of serum apolipoprotein A1 versus apolipoprotein B-to-apolipoprotein A1 ratio in predicting severe acute pancreatitis[J]. J Clin Hepatol, 2020, 36(3): 631-635. DOI: 10.3969/j.issn.1001-5256.2020.03.032.
Citation: Zhong Rui, Xu Huan, Peng Yan, Yan YongFeng, Jiang Xin, Wang Min, Fu WenGuang, Tang XiaoWei. Value of serum apolipoprotein A1 versus apolipoprotein B-to-apolipoprotein A1 ratio in predicting severe acute pancreatitis[J]. J Clin Hepatol, 2020, 36(3): 631-635. DOI: 10.3969/j.issn.1001-5256.2020.03.032.

血清载脂蛋白A1和载脂蛋白B/A1比值对重型急性胰腺炎的预测价值

DOI: 10.3969/j.issn.1001-5256.2020.03.032
基金项目: 

泸州市科技局基金(17246); 泸州市三方联合基金(Z1437); 西南医科大学附属医院科研基金(07037);西南医科大学附属医院博士启动基金(16229); 

详细信息
  • 中图分类号: R576

Value of serum apolipoprotein A1 versus apolipoprotein B-to-apolipoprotein A1 ratio in predicting severe acute pancreatitis

Research funding: 

 

  • 摘要: 目的探索与发现能早期预测重型急性胰腺炎(SAP)的血脂指标,并评估其预测价值。方法回顾性分析2017年1月-2019年1月西南医科大学附属医院收治的425例急性胰腺炎(AP)患者的临床资料,其中轻型急性胰腺炎(MAP) 229例,中度重型急性胰腺炎(MSAP) 161例,SAP 35例,收集所有患者在入院最初24 h内血脂相关数据。计量资料多组间比较采用单因素方差分析或Kruskal-Wallis H秩和检验。将单因素分析中有统计学意义的变量进行多因素logistic回归分析。Spearman相关性分析用于评价数据间的相关性。受试者工作特征曲线(ROC曲线)用于评价指标的诊断效能,MedCalc软件检验其效能差异有无统计学意义。结果载脂蛋白A1(ApoA1)、ApoB/A1在不同严重程度的AP组间差异有统计学意义(F=46. 290、χ2=9. 130,P值均<0. 05)。ApoB/A1与亚特兰大分级、Ranson评分、MCTSI评分、BISAP评分呈正相关(r值分别为0. 296、0. 129、0. 303、0. 284,P值均<0. 05),Ap...

     

  • [1] LEPPANIEMI A,TOLONEN M,TARASCONI A,et al. 2019WSES guidelines for the management of severe acute pancreatitis[J]. World J Emerg Surg,2019,14(1):27.
    [2] BANKS PA,BOLLEN TL,DERVENIS C,et al. Classification of acute pancreatitis—2012:Revision of the Atlanta classification and definitions by international consensus[J]. Gut,2013,62(1):102-111.
    [3] PENG YS,CHEN YC,TIAN YC,et al. Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis[J]. Crit Care,2015,19(1):88.
    [4] ZHONG L,LI Q,JIANG Y,et al. The ApoB/ApoAI ratio is associated with metabolic syndrome and its components in a Chinese population[J]. Inflammation,2010,33(6):353.
    [5] ENKHMAA B,ANUURAD E,ZHANG Z,et al. Usefulness of apolipoprotein B/apolipoprotein A-I ratio to predict coronary artery disease independent of the metabolic syndrome in African Americans[J]. Am J Cardiol,2010,106(9):1264-1269.
    [6] JI HH,JUNG S,CHO SK,et al. Predictive value of apolipoprotein B and A-I ratio in severe acute pancreatitis[J]. J Gastroenterol Hepatol,2018,33(2):548-553.
    [7] WU J,WANG Y,LI H,et al. Serum apolipoprotein B-toapolipoprotein AI ratio is independently associated with disease severity in patients with acute pancreatitis[J]. Sci Rep,2019,9(1):7764.
    [8] GARG PK,SINGH VP. Organ failure due to systemic injury in acute pancreatitis[J]. Gastroenterology,2019,156(7):2008-2023.
    [9] JAHANGIRI DA. HDL and the acute phase response[J]. Curr Opin Endocrinol,2010,17(2):156.
    [10] BOSQUESPADILLA FJ,VAZQUEZELIZONDO G,GONZALEZSANTIAGO O,et al. Hypertriglyceridemia-induced pancreatitis and risk of persistent systemic inflammatory response syndrome[J]. Am J Med Sci,2015,349(3):206-211.
    [11] ZHOU CL,ZHANG CH,ZHAO XY,et al. Early prediction of persistent organ failure by serum apolipoprotein A-I and high-density lipoprotein cholesterol in patients with acute pancreatitis[J]. Clin Chim Acta,2018,476:139-145.
    [12] NAWAZ H,KOUTROUMPAKIS E,EASLER J,et al. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis[J]. Am J Gastroenterol,2015,110(10):1497-1503.
    [13] GAO F,YAN Z,ZHANG J. The relationship between the level of triglyceride and the severity of acute hypertriglyceridemia pancreatitis[J]. J Clin Hepatol,2018,34(11):2360-2363.(in Chinese)高峰,闫真,张杰.甘油三酯水平与急性高甘油三酯血症性胰腺炎严重程度的关系[J].临床肝胆病杂志,2018,34(11):2360-2363.
    [14] VUILLEUMIER N,DAYER JM,von ECKARDSTEIN A,et al.Pro-or anti-inflammatory role of apolipoprotein A-I in high-density lipoproteins?[J]. Swiss Med Wkly,2013,143(10):w13781.
    [15] SIRNIO P,VAYRYNEN JP,KLINTRUP K,et al. Decreased serum apolipoprotein AI levels are associated with poor survival and systemic inflammatory response in colorectal cancer[J].Sci Rep,2017,7(1):5374.
    [16] FARAJ M,MESSIER L,BASTARD JP,et al. Apolipoprotein B:A predictor of inflammatory status in postmenopausal overweight and obese women[J]. Diabetologia,2006,49(7):1637-1646.
    [17] HE WH,LYU NH,ZHENG X,et al. Comparison of APACHE II,Ranson,BISAP and CTSI scores based on large sample database to predict the severity of acute pancreatitis in the early stage[J]. Chin J Pancreatol,2019,19(3):172-176.(in Chinese)何文华,吕农华,郑西,等.基于大样本数据库比较APACHEⅡ、Ranson、BISAP和CTSI评分在早期预测急性胰腺炎病情严重程度[J].中华胰腺病杂志,2019,19(3):172-176.
    [18] LI D,LIU FK,WANG GX. Predictive value of RDW,MPV combined inflammatory indicators,PCT,APACHEII score in acute pancreatitis[J]. J Clin Exp Med,2019,18(18):1943-1947.(in Chinese)李丹,刘凤奎,王国兴.RDW、MPV联合炎症指标、PCT及APACHEII评分对急性胰腺炎病情的预测价值[J].临床和实验医学杂志,2019,18(18):1943-1947.
    [19] YAN YY,ZHANG J,JIN EH. Study on the application of modified CT and MR severity indices in patients with acute pancreatitis[J]. J Clin Exp Med,2018,17(10):1037-1039.(in Chinese)闫媛媛,张洁,靳二虎.改良CT和MR严重指数在急性胰腺炎诊断中的应用研究[J].临床和实验医学杂志,2018,17(10):1037-1039.
    [20] VASUDEVAN S,GOSWAMI P,SONIKA U,et al. Comparison of various scoring systems and biochemical markers in predicting the outcome in acute pancreatitis[J]. Pancreas,2018,47(1):65-71.
    [21] KHANNA AK,MEHER S,PRAKASH S,et al. Comparison of Ranson,Glasgow,MOSS,SIRS,BISAP,APACHE-II,CTSI Scores,IL-6,CRP,and procalcitonin in predicting severity,organ failure,pancreatic necrosis,and mortality in acute pancreatitis[J]. HPB Surg,2013,2013:367581.
    [22] CHO JH,KIM TN,CHUNG HH,et al. Comparison of scoring systems in predicting the severity of acute pancreatitis[J].World J Gastroenterol,2015,21(8):2387-2394.
  • 期刊类型引用(10)

    1. 刘峰,江伟芳. 血清红细胞分布宽度 载脂蛋白B/载脂蛋白A1比值对急性胰腺炎患者疾病严重程度相关性及预测评估价值. 基层医学论坛. 2024(13): 119-122 . 百度学术
    2. 刘妮,史光华,崔雯,贺建超,程江雅. RDW、MPV、AMY及LPS在急性胰腺炎诊断及病情判断中的意义. 检验医学与临床. 2022(04): 489-492 . 百度学术
    3. 刘锦波. 外周血RDW-CV/Ca和ApoB/A_1在急性胰腺炎患者中的检测价值. 中外医学研究. 2022(20): 73-76 . 百度学术
    4. 张永军,徐淼. ApoB/ApoA1比值对2型糖尿病患者早期糖尿病肾病的预测价值. 医学理论与实践. 2022(24): 4258-4260 . 百度学术
    5. 冀文敏,姜丽君,卫彦芳,王文艳. 血清红细胞分布宽度、ApoB/A1对急性胰腺炎患者疾病严重程度及预后的预测价值. 中华生物医学工程杂志. 2022(06): 683-687 . 百度学术
    6. 李涛,费素娟. 实验室指标对急性胰腺炎发生器官衰竭的预测价值. 中国中西医结合消化杂志. 2021(03): 218-221 . 百度学术
    7. 欧阳小予,孙娟,陈永梅. 血脂水平对急性胰腺炎严重程度与预后的评估价值. 医学理论与实践. 2021(15): 2687-2690 . 百度学术
    8. 李涛,费素娟. APOB/APOA1和TG/HDL-C对急性胰腺炎患者发生持续性器官衰竭的预测. 胃肠病学和肝病学杂志. 2021(07): 740-747 . 百度学术
    9. 刘松华,莫湘,黄大荣,陈艳斌,李明灯,莫瑶. HBV阳性与肝内胆汁淤积症对重症急性胰腺炎患者预后的交互作用. 广西医学. 2021(10): 1190-1193 . 百度学术
    10. 付永娟. 血清穿透素-3 载脂蛋白B/载脂蛋白A1 可溶性白细胞介素2受体水平变化与重症急性胰腺炎患者Ranson评分的关联性分析. 实用医技杂志. 2021(10): 1218-1221 . 百度学术

    其他类型引用(5)

  • 加载中
计量
  • 文章访问数:  1543
  • HTML全文浏览量:  65
  • PDF下载量:  196
  • 被引次数: 15
出版历程
  • 收稿日期:  2019-09-23
  • 出版日期:  2020-03-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回