microRNA在HBV感染相关疾病中的作用

刘莉莉; 苏何玲; 刘永明

doi:10.3969/j.issn.1001-5256.2020.03.041

microRNA在HBV感染相关疾病中的作用

DOI: 10.3969/j.issn.1001-5256.2020.03.041

桂林医学院生物化学与分子生物学教研室

基金项目:

国家自然科学基金资助项目(81560341)；广西自然科学基金资助项目(2018GXNSFAA138153)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2019-10-29
- 出版日期: 2020-03-20

Role of microRNA in hepatitis B virus infection-related diseases

Department of Biochemistry and Molecular Biology,Guilin Medical University

Research funding:

摘要

摘要: microRNA(miRNA)通过调控转录后基因表达在病毒性疾病中发挥重要作用。miRNA可影响HBV在宿主细胞内复制和基因表达,而HBV则可通过调节宿主miRNA的表达为自身存活和复制提供有利的环境。这种miRNA介导的HBV与宿主的相互关系是HBV感染相关疾病发病机制的重要基础。阐述了miRNA在HBV感染相关慢性乙型肝炎﹑肝硬化﹑肝细胞癌中的作用进展。
- 肝疾病 /
- 微RNAs /
- 肝炎病毒,乙型
Abstract: MicroRNA( miRNA) plays an important role in viral diseases by regulating post-transcriptional gene expression. MiRNA can affect the replication and gene expression of hepatitis B virus( HBV) in host cells,while HBV can regulate the expression of host miRNA to provide a favorable environment for its own survival and replication. This miRNA-mediated relationship between HBV and host is an important basis for the pathogenesis of HBV infection-related diseases. This article reviews the research advances in the role of miRNA in HBV infection-related chronic hepatitis B,liver cirrhosis,and hepatocellular carcinoma.
- liver diseases /
- microRNAs /
- hepatitis B virus

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参考文献(40)

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