化疗药物致肝损伤的作用机制

方凯; 许健; 徐可; 詹月萍

doi:10.3969/j.issn.1001-5256.2020.03.045

化疗药物致肝损伤的作用机制

DOI: 10.3969/j.issn.1001-5256.2020.03.045

上海中医药大学附属普陀医院中心实验室

基金项目:

上海中医药大学预算内项目(2019LK039)；上海市普陀区中心医院育英计划(2016219A)；

详细信息

中图分类号: R575
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-15
- 出版日期: 2020-03-20

Mechanism of action of chemotherapy drugs in promoting liver injury

Central Laboratory,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 药物是造成肝损伤的重要原因,据统计约1100种药物可能造成肝损伤。由于难以鉴别诊断,药物相关损害仍然被误判。而不同的药物对于肝脏的损伤机制及程度均有不同,因此应对措施也应当具有针对性。有关化疗药物所造成的肝损伤的系统回顾较少。主要介绍了各类用于临床的化疗药物对肝脏的毒性机制,评述了不同化疗药物对肝脏的毒性程度。总结了化疗药物所致肝损伤的临床表现并为临床应对提出相关建议。
- 药物性肝损伤 /
- 化学,药物 /
- 治疗学
Abstract: Drugs are an important cause of liver injury,and according to statistics,about 1100 drugs may induce liver injury. Due to the difficulty in differential diagnosis,drug-related liver injury is still misjudged. As different drugs have different mechanisms of action in inducing liver injury and may cause different degrees of liver injury,targeted countermeasures should be adopted. There are fewer systematic reviews of liver injury caused by chemotherapy drugs. This article mainly introduces the hepatotoxic mechanisms of various chemotherapy drugs,elaborates on the degree of hepatotoxicity caused by chemotherapy drugs,summarizes the clinical manifestations of liver injury caused by chemotherapy drugs,and gives recommendations to clinical treatment.
- drug-induced liver injury /
- chemistry,pharmaceutical /
- therapeutics

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参考文献(22)

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