化疗药物致肝损伤的作用机制

方凯; 许健; 徐可; 詹月萍

doi:10.3969/j.issn.1001-5256.2020.03.045

化疗药物致肝损伤的作用机制

DOI: 10.3969/j.issn.1001-5256.2020.03.045

上海中医药大学附属普陀医院中心实验室

基金项目:

上海中医药大学预算内项目(2019LK039)；上海市普陀区中心医院育英计划(2016219A)；

详细信息

中图分类号: R575
计量
- 文章访问数: 1238
- HTML全文浏览量: 30
- PDF下载量: 291
- 被引次数: 0
出版历程
- 收稿日期: 2019-10-15
- 出版日期: 2020-03-20

Mechanism of action of chemotherapy drugs in promoting liver injury

Central Laboratory,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 药物是造成肝损伤的重要原因,据统计约1100种药物可能造成肝损伤。由于难以鉴别诊断,药物相关损害仍然被误判。而不同的药物对于肝脏的损伤机制及程度均有不同,因此应对措施也应当具有针对性。有关化疗药物所造成的肝损伤的系统回顾较少。主要介绍了各类用于临床的化疗药物对肝脏的毒性机制,评述了不同化疗药物对肝脏的毒性程度。总结了化疗药物所致肝损伤的临床表现并为临床应对提出相关建议。
- 药物性肝损伤 /
- 化学,药物 /
- 治疗学
Abstract: Drugs are an important cause of liver injury,and according to statistics,about 1100 drugs may induce liver injury. Due to the difficulty in differential diagnosis,drug-related liver injury is still misjudged. As different drugs have different mechanisms of action in inducing liver injury and may cause different degrees of liver injury,targeted countermeasures should be adopted. There are fewer systematic reviews of liver injury caused by chemotherapy drugs. This article mainly introduces the hepatotoxic mechanisms of various chemotherapy drugs,elaborates on the degree of hepatotoxicity caused by chemotherapy drugs,summarizes the clinical manifestations of liver injury caused by chemotherapy drugs,and gives recommendations to clinical treatment.
- drug-induced liver injury /
- chemistry,pharmaceutical /
- therapeutics

HTML全文

参考文献(22)

[1] YUAN L,YANG YG,SHEN YX,et al. Research advances in drug-induced liver injury[J]. J Clin Hepatol,2017,33(2):375-378.(in Chinese)袁玲，杨永耿，沈有秀，等．药物性肝损伤的研究进展[J]．临床肝胆病杂志，2017,33(2):375-378.

[2] LUO AF. A Research survey of liver injury induced by common antineoplastic drugs[J]. Med Recapitulate,2010,16(24):3725-3727.(in Chinese)罗安福．常用抗肿瘤药物致肝损害的研究概况[J]．医学综述，2010,16(24):3725-3727.

[3] XIA LY. Progression of breast cancer chemotherapy-associated liver injury[J]. Med J West China,2017,29(5):737-740.(in Chinese)夏林玉．乳腺癌化疗相关性肝损伤的研究进展[J]．西部医学，2017,29(5):737-740.

[4] TIAN Q. Influencing factors for abnormal liver function after chemotherapy for colorectal cancer[D]. Jinan:Shandong University,2017.(in Chinese)田琦．结直肠癌化疗后肝功能异常的影响因素分析[D]．济南:山东大学，2017.

[5] ZHAO YH,YANG GJ,QI LJ,et al. Research advances in the antitumor effect of 5-fluorouracil and its derivatives[J]. Oncol Progr,2019,17(1):9-12.(in Chinese)晁艳红，杨广建，齐丽娟，等．5-氟尿嘧啶及其衍生物抗肿瘤作用的研究进展[J]．癌症进展，2019,17(1):9-12.

[6] WANG CH,WANG S,PENG DQ,et al. Protective effect of whole-tree agarwood-inducing technique-produced agarwood alcohol extracts on the fluorouracil-induced liver injury in mice[J]. J Int Pharm Res,2018,45(3):187-197.(in Chinese)王灿红，王帅，彭德乾，等．通体沉香醇提物对氟尿嘧啶致小鼠肝损伤的保护作用[J]．国际药学研究杂志，2018,45(3):187-197.

[7] YU LH,WEI HL,BAO XQ,et al. Protection of bicyclol on hepatic injury induced by the combination therapy of oxaliplatin and 5-fluorouracil in tumor-bearing mice[J]. Chin J Pharmacov,2013,10(2):68-70.(in Chinese)余凌虹，魏怀玲，鲍秀琦，等．双环醇对奥沙利铂联合5-氟尿嘧啶方案引起肝损伤保护作用的实验研究[J]．中国药物警戒，2013,10(2):68-70.

[8] ALOIA T,SEBAGH M,PLASSE M,et al. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases[J]. J Clin Oncol,2006,24(31):4983-4990.

[9] KANG LB,HOU XL,ZHANG HN. Change in hepatocellular mitochondria in liver injury caused by docetaxel combined with gemcitabine[J]. Chin Hepatol,2019,24(12):1427-1429.(in Chinese)康芦兵，侯晓磊，张海宁．多烯紫杉醇联合吉西他滨致肝损伤时肝细胞线粒体的变化[J]．肝脏，2019,24(12):1427-1429.

[10] YAMASHITA YI,IMAI K,MIMA K,et al. Idiosyncratic druginduced liver injury:A short review[J]. Hepatol Commun,2017,1(6):494-500.

[11] HE L,XU JL,GUO LM,et al. Nrf2/ARE signaling protects against oxaliplatin-induced hepatotoxicity in mice[J]. J Chin Pharm Sci,2017,26(10):709-718.

[12] WANG F. Can we cope with liver injury caused by chemotherapy?[J]. Chin Hepatol,2017,22(9):781-782.(in Chinese)王方．化学治疗引发的肝损伤我们能够应对吗?[J]．肝脏，2017,22(9):781-782.

[13] KELLAND L. The resurgence of platinum-based cancer chemotherapy[J]. Nat Rev Cancer,2007,7(8):573-584.

[14] ALMAGHRABI OA. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney[J]. Saudi J Biol Sci,2015,22(2):227-231.

[15] DASARI S,TCHOUNWOU PB. Cisplatin in cancer therapy:Molecular mechanisms of action[J]. Eur J Pharmacol,2014,740:364-378.

[16] WANG X,ZHAO W,LIU JL,et al. Effect of ephedra water extract on liver injury induced by cisplatin[J]. Int J Traditl Chin Med,2019,41(3):269-272.(in Chinese)王雪，赵婉，刘佳丽，等．麻黄水提物对顺铂致大鼠肝损伤的影响[J]．国际中医中药杂志，2019,41(3):269-272.

[17] SHI YK,BA Y,FENG JF,et al. Expert consensus on the characteristics of anthracyclines in China[J]. Chin J Clin Oncol,2018,45(3):109-112.(in Chinese)石远凯，巴一，冯继锋，等．中国蒽环类药物特性专家共识[J]．中国肿瘤临床，2018,45(3):109-112.

[18] GU JF. Current views on the mechanism of doxorubicin-induced cardiotoxicity and its prevention[J]. World Notes on Antibiotics,2017,38(4):145-151.(in Chinese)顾觉奋．多柔比星毒副作用机制及其防治研究进展[J]．国外医药(抗生素分册)，2017,38(4):145-151.

[19] XU WC. Mechanism of action of the antitumor drug paclitaxel[J]. J Binzhou Med Univ,2017,40(4):294-297.(in Chinese)徐晚成．抗癌药物紫杉醇的作用机理及机制[J]．滨州医学院学报，2017,40(4):294-297.

[20] LI X. Efficacy observation of bicyclol in prevention of liver injury caused by chemotherapy in postoperative breast cancer[J].China Prac Med,2017,12(28):91-92.(in Chinese)李响．乳腺癌术后应用双环醇预防化疗肝损伤的疗效观察[J]．中国实用医药，2017,12(28):91-92.

[21] HUA XM,PENG H,WANG JT,et al. Application effect of Docetaxel in chemotherapy for advanced non-small cell lung cancer[J]. China Modern Med,2019,26(23):53-55.(in Chinese)花小梅，彭辉，王江涛，等．多西紫杉醇在晚期非小细胞肺癌化疗中的应用效果[J]．中国当代医药，2019,26(23):53-55.

[22] YE DM,WEI HM,LAN S,et al. An experimental study of liver damage caused by paclitaxel and docetaxel[J]. Lishizhen Med Mater Med Res,2011,22(1):182-184.(in Chinese)叶冬梅，韦海明，兰顺，等．紫杉醇和多烯紫杉醇致肝损害的实验研究[J]．时珍国医国药，2011,22(1):182-184.

施引文献

资源附件(0)

访问统计