代谢综合征与胆囊结石的关系

白济东; 薛荣泉; 白永乐; 夏医君; 王烯冬; 希龙夫; 韩晓月; 韩立博

doi:10.3969/j.issn.1001-5256.2020.03.052

代谢综合征与胆囊结石的关系

DOI: 10.3969/j.issn.1001-5256.2020.03.052

1. 内蒙古医科大学研究生学院
2. 内蒙古自治区人民医院肝胆胰脾外科
3. 忻州现代医院普外科
4. 内蒙古自治区人民医院急诊医学科

基金项目:

内蒙古自治区自然科学基金面上项目(2019MS08086)；内蒙古自治区科技计划项目(201702118)；内蒙古自治区人民医院院内基金项目(201808)；

详细信息

中图分类号: R575.62;R589
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出版历程
- 收稿日期: 2019-09-23
- 出版日期: 2020-03-20

Association between metabolic syndrome and gallstones

Graduate School of Inner Mongolia Medical University

Research funding:

摘要

摘要: 近年越来越多的患者在患有代谢综合征的同时患有胆囊结石,且胆囊结石极有可能引发急性胆囊炎、急性梗阻性胆管炎、胰腺炎等危及生命的病症。总结分析代谢综合征中肥胖、高血脂、高血糖、高血压与胆囊结石的关系,并对相关机制进行探讨,以期为胆囊结石的筛查、诊断、治疗及预防等提供临床指导。
- 代谢综合征 /
- 胆囊结石病 /
- 危险因素
Abstract: In recent years,more and more patients with metabolic syndrome also have gallstones,and gallstones may lead to life-threatening diseases such as acute cholecystitis,acute obstructive cholangitis,and pancreatitis. This article summarizes the association of obesity,hyperlipidemia,hyperglycemia,and hypertension in metabolic syndrome with gallstones and discusses related mechanisms,in order to provide guidance for the screening,diagnosis,treatment,and prevention of gallstones.
- metabolic syndrome /
- cholecystolithiasis /
- risk factors

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参考文献(35)

[1] ENGIN A. The definition and prevalence of obesity and metabolic syndrome[J]. Adv Exp Med Biol,2017,960:1-17.

[2] ANSARIMOGHADDAM A,ADINEH HA,ZAREBAN I,et al.Prevalence of metabolic syndrome in Middle-East countries:Meta-analysis of cross-sectional studies[J]. Diabetes Metab Syndr,2018,12(2):195-201.

[3] CHENG YA,TAN SY,LI M,et al. Relationship between reflux esophagitis and related factors of metabolic syndrome[J].China Med Herald,2019,16(10):92-95.(in Chinese)程怡安，谭诗云，李明，等．反流性食管炎与代谢综合征相关因素的关系[J]．中国医药导报，2019,16(10):92-95.

[4] HE Q,ZHANG H,LYU D,et al. Study on the correlation between components of metabolic syndrome and colorectal villous adenoma[J]. J Clin Exp Med,2019,18(5):519-521.(in Chinese)何强，张辉，吕栋，等．代谢综合征相关组分与结直肠绒毛状腺瘤相关性研究[J]．临床和实验医学杂志，2019,18(5):519-521.

[5] GLASS CK,WITZTUM JL. Atherosclerosis the road ahead[J].Cel,2001,104(4):503-516.

[6] SU PY,HSU YC,CHENG YF,et al. Strong association between metabolically-abnormal obesity and gallstone disease in adults under 50 years[J]. BMC Gastroenterol,2019,19(1):117.

[7] YANG SD,FANG DL,ZHU ZF. Correlation analysis of metabolic syndrome and calculous cholecystitis[J]. J Clin Surg,2014,27(6):417-418.(in Chinese)杨树鼎，方东临，朱政峰．代谢综合征与胆囊结石症状发生的相关性分析[J]．临床外科杂志，2014,27(6):417-418.

[8] STENDER S,NORDESTGAARD BG,TYBJAERG-HANSEN A. Elevated body mass index as a causal risk factor for symptomatic gallstone disease:A Mendelian randomization study[J]. Hepatology,2013,58(6):2133-2141.

[9] CHEN Z. Research advances in the diagnosis and treatment of acute cholecystitis in pregnancy and childbirth[J]. Chin J Curr Adv Gen Surg,2018,21(3):242-245.(in Chinese)陈政．孕产期合并急性胆囊炎的诊断与治疗进展[J]．中国现代普通外科进展，2018,21(3):242-245.

[10] HAN XY,XUE RQ,XIA YJ,et al. Progress of research on animal model of biliary calculi[J/CD]. Chin J Injury Repair and Wound Healing(Electronic Edition),2017,12(6):470-472.(in Chinese)韩晓月，薛荣泉，夏医君，等．胆道结石动物模型的研究进展[J/CD]．中华损伤与修复杂志(电子版)，2017,12(6):470-472.

[11] LEI ZM,YE MX,FU WG,et al. Levels of serum leptin,cholecystokinin,plasma lipid and lipoprotein differ between patients with gallstone or/and those with hepatolithiasis[J]. Hepatobiliary Pancreat Dis Int,2008,7(1):65-69.

[12] XI LF,XUE RQ,XIA YJ,et al. Function of leptin in gallstone formation[J]. Int J Surg,2017,44(6):383-387.(in Chinese)希龙夫，薛荣泉，夏医君，等．瘦素在胆囊胆固醇结石形成中的作用[J]．国际外科学杂志，2017,44(6):383-387.

[13] GREENBERG AS,OBIN MS. Obesity and the role of adipose tissue in inflammation and metabolism[J]. Am J Clin Nutr,2006,83(2):461s-465s.

[14] JONAS E,MARSK R,RASMUSSEN F,et al. Incidence of postoperative gallstone disease after antiobesity surgery:Population-based study from Sweden[J]. Surg Obes Relat Dis,2010,6(1):54-58.

[15] GUSTAFSSON U,BENTHIN L,GRANSTROM L,et al. Changes in gallbladder bile composition and crystal detection time in morbidly obese subjects after bariatric surgery[J]. Hepatology,2005,41(6):1322-1328.

[16] STOKES CS,GLUUD LL,CASPER M,et al. Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss:A meta-analysis of randomized controlled trials[J].Clin Gastroenterol Hepatol,2014,12(7):1090-1100,e61.

[17] CHEN JH,TSAI MS,CHEN CY,et al. Bariatric surgery did not increase the risk of gallstone disease in obese patients:A comprehensive cohort study[J]. Obes Surg,2019,29(2):464-473.

[18] SARAC S,ATAMER A,ATAMER Y,et al. Leptin levels and lipoprotein profiles in patients with cholelithiasis[J]. J Int Med Res,2015,43(3):385-392.

[19] SUN MM,CAO LY,SUN WD,et al. Association of serum high-density lipoprotein cholesterol with new-onset cholelithiasis[J]. J Clin Hepatol,2019,35(8):1745-1750.(in Chinese)孙苗苗，曹立瀛，孙卫东，等．血清高密度脂蛋白胆固醇与新发胆石症的关系[J]．临床肝胆病杂志，2019,35(8):1745-1750.

[20] GELLERT-KRISTENSEN H,DALILAN,FALLGAARD NS,et al.Identification and replication of six loci associated with gallstone disease[J]. Hepatology,2019,70(2):597-609.

[21] GU TH. Study of bile composition and causes of gallstone in242 cases of biliary surgery[J]. J North Sichuan Med Col,2016,31(6):838-840.(in Chinese)辜天慧．242例胆道手术患者胆汁成分与胆石成因研究[J]．川北医学院学报，2016,31(6):838-840.

[22] BANKS WA,FARR SA,SALAMEH TS,et al. Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance[J]. Int J Obes(Lond),2018,42(3):391-397.

[23] SMELT AH. Triglycerides and gallstone formation[J]. Clin Chim Acta,2010,411(21-22):1625-1631.

[24] MVONDO MA,NJAMEN D,KRETZSCHMAR G,et al. Alpinumisoflavone and abyssinone V 4'-methylether derived from Erythrina lysistemon(Fabaceae)promote HDL-cholesterol synthesis and prevent cholesterol gallstone formation in ovariectomized rats[J]. J Pharm Pharmacol,2015,67(7):990-996.

[25] YAN HJ,CUI NQ,ZHANG SK,et al. Research advances in the association between abnormal lipid metabolism and cholesterol stones[J]. Chin J Surg Integr Tradit West Med,2015,21(4):419-422.(in Chinese)严豪杰，崔乃强，张淑坤，等．脂质代谢异常与胆固醇结石相关性研究进展[J]．中国中西医结合外科杂志，2015,21(4):419-422.

[26] STENDER S,FRIKKE-SCHMIDT R,BENN M,et al. Lowdensity lipoprotein cholesterol and risk of gallstone disease:A Mendelian randomization study and meta-analyses[J]. J Hepatol,2013,58(1):126-133.

[27] LIANG MY,WEI YC,WANG YM,et al. Association between fasting blood glucose and the risk of cholelithiasis[J]. J Clin Hepatol,2019,35(11):2517-2522.(in Chinese)梁明杨，魏垚臣，王一鸣，等．空腹血糖水平与胆石症发病风险的关系[J]．临床肝胆病杂志，2019,35(11):2517-2522.

[28] FANG BJ,SHEN JY,ZHANG H,et al. Albiflorin Granule significantly decreased the cholesterol gallstone formation by the regulation of insulin transduction signal[J]. Asian Pac J Trop Med,2016,9(9):877-881.

[29] NESS GC,EDELMAN JL,BROOKS PA. Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin[J]. Biochem Biophys Res Commun,2012,420(1):178-182.

[30] DORVASH MR,KHOSHNOOD MJ,SABER H,et al. Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice[J]. Eur J Pharmacol,2018,833:165-172.

[31] RAMAKRISHNAN G,ARJUMAN A,SUNEJA S,et al. The association between insulin and low-density lipoprotein receptors[J]. Diab Vasc Dis Res,2012,9(3):196-204.

[32] DUFER M,HORTH K,KRIPPEIT-DREWS P,et al. The significance of the nuclear farnesoid X receptor(FXR)in beta cell function[J]. Islets,2012,4(5):333-338.

[33] NOEL OF,STILL CD,ARGYROPOULOS G,et al. Bile acids,FXR,and metabolic effects of bariatric surgery[J]. J Obes,2016,2016:4390254.

[34] FANG S,SUH JM,REILLY SM,et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance[J]. Nat Med,2015,21(2):159-165.

[35] LOPEZ-JARAMILLO P,GOMEZ-ARBELAZ D,LOPEZ-LOPEZ J,et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes[J]. Horm Mol Biol Clin Investig,2014,18(1):37-45.

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