胰腺癌缺氧微环境的生物学作用

张雨; 江建新

doi:10.3969/j.issn.1001-5256.2020.03.054

胰腺癌缺氧微环境的生物学作用

DOI: 10.3969/j.issn.1001-5256.2020.03.054

张雨,
江建新

武汉大学人民医院肝胆外科

基金项目:

国家自然科学基金(8187101814)；

详细信息

中图分类号: R735.9
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- 被引次数: 0
出版历程
- 收稿日期: 2019-10-10
- 出版日期: 2020-03-20

Biological role of hypoxic microenvironment in pancreatic cancer

Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University

Research funding:

摘要

摘要: 癌细胞生长迅速及中心血供不足导致的缺氧是肿瘤微环境特性之一,在胰腺癌中尤为突出。越来越多的研究显示,缺氧与胰腺癌的血管新生、代谢重建、肿瘤增殖及早期浸润转移密切相关,并通过分泌多种活性因子介导肿瘤免疫逃避。此外,耐药作为胰腺癌治愈率低的关键因素,也与缺氧相关。缺氧与胰腺癌的发生发展密不可分,并依赖于缺氧诱导因子发挥作用。对缺氧微环境与胰腺癌的关系进行了总结,并探讨相关信号通路激活与分子机制,以期为胰腺癌缺氧微环境靶向治疗提供线索。
- 胰腺肿瘤 /
- 缺氧 /
- 肿瘤微环境
Abstract: Hypoxia caused by rapid growth of cancer cells and insufficient central blood supply is one of the characteristics of tumor microenvironment,especially in pancreatic cancer. An increasing number of studies have shown that hypoxia is closely associated with angiogenesis,metabolic reprogramming,tumor proliferation,and early invasion and metastasis of pancreatic cancer and can mediate tumor immune evasion by secreting a variety of active factors. In addition,as a key factor for the low cure rate of pancreatic cancer,drug resistance is also associated with hypoxia. Hypoxia is closely associated with the development and progression of pancreatic cancer and depends on hypoxia-inducible factor. This article summarizes the association between hypoxic microenvironment and pancreatic cancer and discusses the activation of related signaling pathways and molecular mechanisms,in order to provide clues for targeted therapy for hopoxic microenvironment in pancreatic cancer.
- pancreatic neoplasms /
- hypoxia /
- tumor microenvironment

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参考文献(35)

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