自身免疫性肝炎的研究现状与展望

王绮夏; 马雄

doi:10.3969/j.issn.1001-5256.2020.04.001

自身免疫性肝炎的研究现状与展望

DOI: 10.3969/j.issn.1001-5256.2020.04.001

王绮夏,
马雄

上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所

基金项目:

国家自然科学基金项目(81770564,81790634,81620108002,81771732,81830016)；上海市卫生计生系统优秀青年医学人才培养计划(2017YQ037)；上海市青年科技启明星计划(18QA1402700)；

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中图分类号: R575.1
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出版历程
- 出版日期: 2020-04-20

Current status and perspectives of autoimmune hepatitis

Department of Gastroenterology, Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Jiaotong University School of Medicine

Research funding:

摘要

摘要: 自身免疫性肝炎(AIH)是遗传易感个体在环境等因素诱导下出现的自身免疫性肝病,以血清自身抗体阳性、高免疫球蛋白G血症、转氨酶水平升高和界面性肝炎为主要特征。AIH发病机制尚未完全阐明,临床诊治过程中亦有较高异质性,患者个体化的精准医学诊疗显得尤为重要。为此,结合近年来本领域重要研究进展和难点问题进行述评。
- 肝炎,自身免疫性 /
- 治疗学 /
- 预后
Abstract: Autoimmune hepatitis( AIH) is an autoimmune liver disease induced by environmental factors in individuals with genetic susceptibility,with the main features of positive serum autoantibody,hypergammaglobulinemia,elevated transaminases,and interface hepatitis.The pathogenesis of AIH remains unknown,high heterogeneity is observed in clinical diagnosis and treatment,and thus it is of great importance to establish individualized precise diagnosis and treatment. Therefore,this article reviews the research advances and difficult issues in this field.
- hepatitis,autoimmune /
- therapeutics /
- prognosis

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参考文献(22)

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