Successful treatment of autoimmune hepatitis-like drug-induced subacute-on-chronic liver failure: A case report
-
摘要:
<正>药物性肝损伤(DILI)是由于药物理化性质和宿主因素相互作用所诱发的肝损伤[1]。其发病机制复杂,临床表现多样,部分可慢性化,还可发生自身免疫性肝炎(AIH)或自身免疫性肝炎样现象,甚至导致肝衰竭,给诊断和治疗带来一定困难。本文报道1例自身免疫性肝炎样的药物性慢加亚急性肝衰竭成功救治的患者,以供临床参考。
-
Key words:
- drug-induced liver injury /
- hepatitis,autoimmune /
- liver failure /
- glucocorticoids
-
[1] HU Q,LIU W,SHAO H. Research progress of pharmacotherapy drug-induced liver injury[J]. Chin J Clin Pharmacol Ther,2016,21(2):231-236.(in Chinese)胡琴,刘维,邵宏.药物性肝损伤的药物治疗研究进展[J].中国临床药理学与治疗学,2016,21(2):231-236. [2] CHALASANI NP,HAYASHI PH,BONKOVSKY HL,et al. ACG clinical guidline:The diagnosis and management of idiosyncratic drug-induced liver injury[J]. Am J Gastroenterol,2014,109(7):950-967. [3] Drug-induced Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Clin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志,2015,31(11):1752-1769. [4] HOU FQ,ZENG Z,WANG GQ. Hospital admissions for druginduced liver injury:Clinical feature,therapy,and outcomes[J]. Cell Biochem Biophys,2012,64(2):77-83. [5] FONTANA RJ,SEEF LB,ANDRADE RJ,et al. Standardization of nomenclature and causality assessment in drug-induced liver injury:Summary of a clinical research workshop[J].Hepatology,2010,52(2):730-742. [6] FONTANA RJ,HAYASHI PH,GU J,et al. Idiosyncratic druginduced liver injury is associated with substantial morbidity and mortality within 6 months from onset[J]. Gastroenterology,2014,147(1):96-108. [7] CHALASANI N,BONKOVSKY HL,FONTANA R,et al. Features and outcomes of 899 patients with drug-induced liver injury:The DILIN prospective study[J]. Gastroenterology,2015,148(7):1340-1352. [8] de BOER YS,KOSINSKI AS,URBAN TJ,et al. Features of autoimmune hepatitis in patients with drug-induced liver injury[J]. Clin Gastroenterol Hepotol,2017,15(1):103-112. [9] FU XH,LI GH. Research advances in the hepatotoxicity of cyclosporin A[J]. Foreign Med Sci:Pharm,1997,24(1):34-37.(in Chinese)傅晓辉,李光辉.环孢菌素A的肝脏毒性作用研究进展[J].国外医学·药学分册,1997,24(1):34-37. [10] FANG SX,LIU D,YUAN LN,et al. Hepatotoxicity of cyclosporin A after kidney transplantation[J]. Chin Hosp Pharm J,2003,23(4):224-225.(in Chinese)方淑贤,刘东,苑丽娜,等.肾移植术后环孢素A肝毒性研究[J].中国医院药学杂志,2003,23(4):224-225. [11] CHEN XY,WU HF,QIAN LX. An experimental study of the hepatotoxicity of cyclosporin A in rats[J]. Acta Univ Med Nanjing,2001,21(4):337-338.(in Chinese)陈晓宇,吴宏飞,钱立新.环孢素A对大鼠肝毒性的实验研究[J].南京医科大学学报,2001,21(4):337-338.
计量
- 文章访问数: 946
- HTML全文浏览量: 8
- PDF下载量: 207
- 被引次数: 0