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自身免疫性肝炎样的药物性慢加亚急性肝衰竭成功救治1例报告

张杰 李璐 刘晖 邹怀宾 陈煜 郑素军

引用本文:
Citation:

自身免疫性肝炎样的药物性慢加亚急性肝衰竭成功救治1例报告

DOI: 10.3969/j.issn.1001-5256.2020.04.034
基金项目: 

艾滋病和病毒性肝炎等重大传染病防治(国家科技攻关计划)国家135科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”专项资助(2017ZX10202203-006-001,2017ZX10302201-004-002); 

详细信息
  • 中图分类号: R575

Successful treatment of autoimmune hepatitis-like drug-induced subacute-on-chronic liver failure: A case report

Research funding: 

 

  • 摘要:

    <正>药物性肝损伤(DILI)是由于药物理化性质和宿主因素相互作用所诱发的肝损伤[1]。其发病机制复杂,临床表现多样,部分可慢性化,还可发生自身免疫性肝炎(AIH)或自身免疫性肝炎样现象,甚至导致肝衰竭,给诊断和治疗带来一定困难。本文报道1例自身免疫性肝炎样的药物性慢加亚急性肝衰竭成功救治的患者,以供临床参考。

     

  • [1] HU Q,LIU W,SHAO H. Research progress of pharmacotherapy drug-induced liver injury[J]. Chin J Clin Pharmacol Ther,2016,21(2):231-236.(in Chinese)胡琴,刘维,邵宏.药物性肝损伤的药物治疗研究进展[J].中国临床药理学与治疗学,2016,21(2):231-236.
    [2] CHALASANI NP,HAYASHI PH,BONKOVSKY HL,et al. ACG clinical guidline:The diagnosis and management of idiosyncratic drug-induced liver injury[J]. Am J Gastroenterol,2014,109(7):950-967.
    [3] Drug-induced Liver Disease Study Group,Chinese Society of Hepatology,Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Clin Hepatol,2015,31(11):1752-1769.(in Chinese)中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志,2015,31(11):1752-1769.
    [4] HOU FQ,ZENG Z,WANG GQ. Hospital admissions for druginduced liver injury:Clinical feature,therapy,and outcomes[J]. Cell Biochem Biophys,2012,64(2):77-83.
    [5] FONTANA RJ,SEEF LB,ANDRADE RJ,et al. Standardization of nomenclature and causality assessment in drug-induced liver injury:Summary of a clinical research workshop[J].Hepatology,2010,52(2):730-742.
    [6] FONTANA RJ,HAYASHI PH,GU J,et al. Idiosyncratic druginduced liver injury is associated with substantial morbidity and mortality within 6 months from onset[J]. Gastroenterology,2014,147(1):96-108.
    [7] CHALASANI N,BONKOVSKY HL,FONTANA R,et al. Features and outcomes of 899 patients with drug-induced liver injury:The DILIN prospective study[J]. Gastroenterology,2015,148(7):1340-1352.
    [8] de BOER YS,KOSINSKI AS,URBAN TJ,et al. Features of autoimmune hepatitis in patients with drug-induced liver injury[J]. Clin Gastroenterol Hepotol,2017,15(1):103-112.
    [9] FU XH,LI GH. Research advances in the hepatotoxicity of cyclosporin A[J]. Foreign Med Sci:Pharm,1997,24(1):34-37.(in Chinese)傅晓辉,李光辉.环孢菌素A的肝脏毒性作用研究进展[J].国外医学·药学分册,1997,24(1):34-37.
    [10] FANG SX,LIU D,YUAN LN,et al. Hepatotoxicity of cyclosporin A after kidney transplantation[J]. Chin Hosp Pharm J,2003,23(4):224-225.(in Chinese)方淑贤,刘东,苑丽娜,等.肾移植术后环孢素A肝毒性研究[J].中国医院药学杂志,2003,23(4):224-225.
    [11] CHEN XY,WU HF,QIAN LX. An experimental study of the hepatotoxicity of cyclosporin A in rats[J]. Acta Univ Med Nanjing,2001,21(4):337-338.(in Chinese)陈晓宇,吴宏飞,钱立新.环孢素A对大鼠肝毒性的实验研究[J].南京医科大学学报,2001,21(4):337-338.
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  • 出版日期:  2020-04-20
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