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自身免疫性肝炎后肝硬化合并原发性免疫性血小板减少1例报告

冯颖 周桂琴 杨莉 李斌 王宪波

引用本文:
Citation:

自身免疫性肝炎后肝硬化合并原发性免疫性血小板减少1例报告

DOI: 10.3969/j.issn.1001-5256.2020.04.035
基金项目: 

北京市自然科学基金青年基金项目(7184219); 北京市科学技术委员会资助(Z191100006619033); 

详细信息
  • 中图分类号: R575.2;R558.2

Autoimmune hepatitis-associated liver cirrhosis with primary immune thrombocytopenia: A case report

Research funding: 

 

  • 摘要:

    <正>自身免疫性肝炎(AIH)是一种由针对肝细胞自身免疫反应所介导的肝脏实质炎症[1]。AIH常合并其他器官或系统性自身免疫性疾病如:桥本氏甲状腺炎(10%~23%)、糖尿病(7%~9%)、炎症性肠病(2%~8%)、类风湿性关节炎(2%~5%)、干燥综合征(1%~4%)、银屑病(3%)和系统性红斑狼疮(1%~2%)等[2]。而合并原发性免疫性血小板减少(primary immune thrombocytopenia,IPT)者少见,国内外均罕见报道。

     

  • [1] SAHEBJAM F,VIERLING JM. Autoimmune hepatitis[J]. Front Med,2015,9(2):187-219.
    [2] LIBERAL R,GRANT CR,MIELI-VERGANI G,et al. Autoimmune hepatitis:A comprehensive review[J]. J Autoimmun,2013,3(41):126-139.
    [3] TERZIROLI BERETTA-PICCOLI B,MIELI-VERGANI G,VERGANI D. Autoimmune hepatitis:Standard treatment and systematic review of alternative treatments[J]. World J Gastroenterol,2017,23(33):6030-6048.
    [4] Chinese Society of Hepatology,Chinese Medical Association;Chinese Society of Gastroenterology,Chinese Medical Association; Chinese Society of Infectious Diseases,Chinese Medical Association. Chinese consensus on the diagnosis and management of autoimmune hepatitis(2015)[J]. J Clin Hepatol,2016,32(1):9-22.(in chinese)中华医学会肝病学分会,中华医学会消化病学分会,中华医学会感染病学分会.自身免疫性肝炎诊断和治疗共识(2015)[J].临床肝胆病杂志,2016,32(1):9-22.
    [5] SAMSON M,FRASER W,LEBOWITZ D. Treatments for primary immune thrombocytopenia:A review[J]. Cureus,2019,11(10):e5849.
    [6] YIN YY,SUN SJ,FANG YG,et al. Clinical efficacy of prednisone acetate in treatment of primary immune thrombocytopenia[J]. Clin J Med Offic,2019,47(12):1352-1354.(in Chinese)尹艳英,孙淑君,方永光,等.醋酸泼尼松治疗原发免疫性血小板减少症临床疗效[J].临床军医杂志,2019,47(12):1352-1354.
    [7] NEUNERT C,LIM W,CROWTHER M,et al. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia[J]. Blood,2011,117(16):4190-4207.
    [8] AFDHAL N,MCHUTCHISON J,BROWN R,et al. Thrombocytopenia associated with chronic liver disease[J]. J Hepatol,2008,48(6):1000-1007.
    [9] ABDELA J. Current advance in thrombopoietin receptor agonists in the management of thrombocytopenia associated with chronic liver disease:Focus on avatrombopag[J]. Clin Med Insights Blood Disord,2019,12:1179545X19875105.
    [10] MARKS PW. Hematologic manifestations of liver disease[J].Semin Hematol,2013,50(3):216-221.
    [11] PECK-RADOSAVLJEVIC M. Thrombocytopenia in chronic liver disease[J]. Liver Int,2017,37(6):778-793.
    [12] ARNAL C,PIETTE JC,LONE J,et al. Treatment of severe immune thrombocytopenia associated with systemic lupus erythematosus:59 cases[J]. J Rheumatol,2002,29(1):75-83.
    [13] MATZDORFF A,WRMANN B. Diagnosis and Therapy of Immune thrombocytopenia[J]. Dtsch Med Wochenschr,2018,143(15):1076-1081.
    [14] VISCO C,RUGGERI M,LAURA EVANGELISTA M,et al. Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia[J]. Blood,2008,111(3):1110-1116.
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  • 出版日期:  2020-04-20
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