HBV介导的肝星状细胞和天然免疫细胞的相互作用

杨苗苗; 邬志惠; 涂正坤

doi:10.3969/j.issn.1001-5256.2020.04.040

HBV介导的肝星状细胞和天然免疫细胞的相互作用

DOI: 10.3969/j.issn.1001-5256.2020.04.040

吉林大学第一医院转化医学研究院

基金项目:

国家自然科学基金项目(81373143,81571535)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2020-04-20

Hepatitis B virus-mediated interaction between hepatic stellate cells and innate immune cells

Research Institute of Translational Medicine, The First Hospital of Jilin University

Research funding:

摘要

摘要: 肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。
- 乙型肝炎病毒 /
- 肝硬化 /
- 肝星状细胞 /
- 单核巨噬细胞系统 /
- 自然杀伤细胞
Abstract: Liver nonparenchymal cells play an important role in hepatitis B virus( HBV)-related liver diseases,and the activation of hepatic stellate cells( HSCs) and their interactions with intrahepatic cells are the main cause of liver fibrosis. This article mainly introduces HBV-induced liver inflammation and the interaction between innate immune cells and HSCs and briefly describes the role of monocytes/macrophages and natural killer cells in the activation and killing of HSCs and the immunomodulatory effect of HSCs in the presence of HBV.
- hepatitis B virus /
- liver cirrhosis /
- hepatic stellate cells /
- mononuclear phagocyte system /
- NK cells

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参考文献(38)

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