氧化应激与核因子E2相关因子2在非酒精性脂肪性肝病中的作用

陆孝良; 蒋元烨; 曹勤

doi:10.3969/j.issn.1001-5256.2020.04.048

氧化应激与核因子E2相关因子2在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2020.04.048

上海中医药大学附属普陀医院

基金项目:

国家自然科学基金青年项目(81703879)；上海市卫计委临床研究专项面上项目(201840377)；上海市普陀区中心医院人才培养项目(2016212B)；上海中医药大学预算内项目(18LK022)；上海市普陀区中心医院院级重点专科项目(2016103A)；

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中图分类号: R575.5
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出版历程
- 出版日期: 2020-04-20

The role of oxidative stress and nuclear factor erythroid 2-related factor 2 in nonalcoholic fatty liver disease

Putuo Hospital, Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 非酒精性脂肪肝病(NAFLD)是全球最流行的慢性肝病,发病率逐年上升。氧化应激是非酒精性脂肪肝病经典"二次打击"发病机制的第二次打击,是目前公认的NAFLD发病机制之一。核因子E2相关因子2(Nrf2)是保护肝细胞免受氧化应激的一组正向调节因子,是细胞抗氧化应激的关键因子,也是拮抗肝脏氧化应激的关键转录因子,在NAFLD发生发展中起重要作用,Nrf2可能是改善NAFLD的潜在治疗靶点。对氧化应激及Nrf2通路在NAFLD中的发病机制进行了综述。
- 非酒精性脂肪性肝病 /
- 氧化性应激 /
- NF-E2相关因子2
Abstract: Nonalcoholic fatty liver disease( NAFLD) is the most prevalent chronic liver disease around the world,and its incidence rate is increasing year by year. Oxidative stress is the second hit in the classic“two-hit”pathogenesis of NAFLD,which is currently recognized as one of the pathogeneses of NAFLD. Nuclear factor erythroid 2-related factor 2( Nrf2) is a group of positive regulators that protect hepatocytes against oxidative stress. It is a key factor for cellular anti-oxidative stress and a key transcription factor that antagonizes liver oxidative stress. It plays an important role in the development and progression of NAFLD and may be a potential treatment target for improving NAFLD. This article reviews the role of oxidative stress and the Nrf2 pathway in the pathogenesis of NAFLD.
- nonalcoholic fatty liver /
- oxidant stress /
- NF-E2-related factor 2

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