外泌体在非肿瘤性肝脏疾病中的研究进展

徐帅; 张立平

doi:10.3969/j.issn.1001-5256.2020.04.052

外泌体在非肿瘤性肝脏疾病中的研究进展

DOI: 10.3969/j.issn.1001-5256.2020.04.052

徐帅,
张立平

1. 北京中医药大学东方医院消化科
2. 北京中医药大学

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2020-04-20

Research advances in the role of exosomes in non-neoplastic liver diseases

Department of Gastroenterology, Dongfang Hospital of Beijing University of Chinese Medicine

摘要

摘要: 肝脏是人体重要的代谢和免疫器官,外泌体是一种由细胞分泌的细胞外囊泡,携带蛋白质、脂质、DNA和RNA等多种分子,研究发现其在多种肝脏疾病中发挥重要作用。阐述了外泌体在非肿瘤性肝脏疾病发病机制中的作用,以及将它们作为疾病诊断生物标志物和治疗手段的相关研究进展,认为应该深入研究外泌体的生物发生、释放及其在疾病中的确切机制,为非肿瘤性肝脏疾病的防治提供依据。
- 肝疾病 /
- 外泌体 /
- 诊断 /
- 治疗学
Abstract: The liver is an important metabolic and immune organ in human body. Exosomes are extracellular vesicles released by cells and carry a variety of molecules such as proteins,lipids,DNA,and RNA. Studies have found that exosomes play an important role in various liver diseases. This article elaborates on the role of exosomes in the pathogenesis of non-neoplastic liver diseases and related research advances in their role as biomarkers for disease diagnosis and therapeutic methods. It is pointed out that in-depth studies are needed to explore the biogenesis and release of exosomes and the exact mechanism of exosomes in liver diseases,in order to provide a basis for the prevention and treatment of non-neoplastic liver diseases.
- liver diseases /
- exosomes /
- diagnosis /
- therapeutics

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参考文献(43)

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