HDV重叠感染可增加慢性乙型肝炎患者的肝细胞癌风险

于哲; 杨永平

doi:10.3969/j.issn.1001-5256.2020.04.053

HDV重叠感染可增加慢性乙型肝炎患者的肝细胞癌风险

DOI: 10.3969/j.issn.1001-5256.2020.04.053

于哲,
杨永平

1. 北京大学三〇二临床医学院
2. 解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心

基金项目:

国家“十三五”科技重大专项(2018ZX10725506)；

详细信息

中图分类号: R512.62;R735.7
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出版历程
- 出版日期: 2020-04-20

Concurrent hepatitis D virus infection increases risk of hepatocellular carcinoma in patients with chronic hepatitis B

Peking University 302 Clinical Medical School

Research funding:

摘要

摘要: HDV的重叠感染可加速慢性乙型肝炎患者的肝病进程,尤其肝细胞癌(HCC)的发生风险明显增高。但HDV的致癌机制有待进一步探索,治疗方式及效果也亟待突破。综述了HDV相关HCC流行病学新特点、致病机制的新认识和诊疗进展等,对推进研发更精准的HDV检测手段、更有效的治疗药物及减少HDV相关HCC具有重要意义。
- 肝炎病毒 /
- 乙型肝炎,慢性 /
- 重叠感染
Abstract: Concurrent hepatitis D virus( HDV) infection accelerates the progression of liver disease in patients with chronic hepatitis B and particularly increases the risk of hepatocellular carcinoma( HCC). Further studies are still needed to explore the carcinogenic mechanism of HDV,related treatment methods,and their clinical effects. This article reviews the new epidemiological characteristics of HDV-related HCC,the new understanding of the pathogenic mechanism of HDV,and the advances in diagnosis and treatment,which is of great significance to promote the development of accurate HDV detection methods and effective drugs and reduce HDV-related HCC.
- hepatitis delta virus /
- hepatitis B,chronic /
- superinfection

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参考文献(44)

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