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N-myc下游调控基因家族在肝细胞癌中的诊断及预后价值

罗琼 王春明 廖航宇 陈锟灵 潘明新

引用本文:
Citation:

N-myc下游调控基因家族在肝细胞癌中的诊断及预后价值

DOI: 10.3969/j.issn.1001-5256.2020.06.019
基金项目: 

广东省自然科学基金(2016A030313626); 

详细信息
  • 中图分类号: R735.7

Value of the NDRG family in the diagnosis and prognostic evaluation of hepatocellular carcinoma

Research funding: 

 

  • 摘要:

    目的基于生物信息挖掘技术,分析N-myc下游调控基因(NDRG)家族在肝细胞癌(HCC)患者组织中的表达情况及与病理特征和预后的相关性。方法利用ONCOMINE、GEPIA和Kaplan-Meier Plotter挖掘了HCC患者的NDRG表达和生存数据。共收集419例HCC组织的基因表达数据分析NDRG家族表达差异,将其分为肝癌组(n=369)和正常肝组织组(n=50)。生存分析共收集364例HCC组织的NDRG家族基因表达数据,分为低表达组[NDRG1(212例)、NDRG2(185例)、NDRG3(182例)、NDRG4(184例)]和高表达组[NDRG1(152例)、NDRG2(179例)、NDRG3(182例)、NDRG4(180例)]。计量资料两组间比较采用t检验,多组间比较采用单因素方差分析,进一步比较采用Dunnett-t检验;生存分析采用log-rank检验。结果 HCC组织中NDRG1/3的表达水平高于正常肝组织,而NDRG2在癌组织中的表达水平低于正常肝组织(P值均<0. 05)。不同病理分期NDRG1/2/3/4表达差异组间比较差异均有统计学意义(F值分别...

     

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  • 出版日期:  2020-06-20
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