核苷(酸)类似物治疗慢性乙型肝炎发生HBeAg血清学转换的预测标志物

蒋莹莹; 郑素军

doi:10.3969/j.issn.1001-5256.2020.06.036

核苷(酸)类似物治疗慢性乙型肝炎发生HBeAg血清学转换的预测标志物

DOI: 10.3969/j.issn.1001-5256.2020.06.036

1. 首都医科大学附属北京佑安医院肝病重症医学科
2. 首都医科大学附属北京佑安医院疑难肝病及人工肝中心
3. 首都医科大学附属北京佑安医院肝衰竭与人工肝治疗研究北京市重点实验室

基金项目:

国家十三五重大科技专项(2017ZX10202203-006);国家十三五重大科技专项(2017ZX10302201-004)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2020-01-15
- 出版日期: 2020-06-20

Research advances in predictive markers for HBeAg seroconversion in chronic hepatitis B patients treated with nucleos( t) ide analogues

Department of Severe Liver Disease,Beijing YouAn Hospital,Capital Medical University
Difficult & Complicated Liver Diseases and Artificial Liver Center,Beijing YouAn Hospital,Capital Medical University
Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research,Beijing YouAn Hospital,Capital Medical University

Research funding:

摘要

摘要:
核苷（酸）类似物（NAs）是HBV复制的有效抑制剂,是目前大多数慢性乙型肝炎（CHB）患者抗病毒治疗的首选治疗方案。HBeAg血清学转换是评价HBeAg阳性CHB患者抗病毒治疗的持久性和有效性的重要指标。寻找能够预测NAs治疗CHB患者后发生HBeAg阴转/血清学转换的生物标志物,对于抗病毒治疗药物的选择、方案的调整、实现个体化治疗至关重要。综述了HBV DNA、HBV RNA、抗-HBc、HBcrAg等标志物对于预测NAs治疗CHB患者HBeAg转阴/血清学转换的价值。
- 乙型肝炎,慢性 /
- 肝炎e抗原,乙型 /
- 核苷类 /
- 核苷酸类
Abstract:
Nucleos( t) ide analogues( NAs) are effective inhibitors for HBV replication and have become the preferred antiviral regimen for most patients with chronic hepatitis B( CHB). HBeAg seroconversion is an important index used to evaluate the durability and efficacy of antiviral therapy in HBeAg-positive CHB patients. The search for biomarkers that can predict HBeAg clearance or seroconversion after NAs treatment plays an important role in the selection of antiviral drugs,the adjustment of treatment regimens,and the achievement of individualized treatment. This article reviews the value of related markers,including HBV DNA,HBV RNA,anti-HBc,and HBcrAg,in predicting HBeAg clearance or seroconversion in CHB patients treated with NAs.
- hepatitis B,chronic /
- hepatitis B e antigens /
- nucleosides /
- nucleotides

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参考文献(43)

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