胆汁酸代谢及其受体在非酒精性脂肪性肝病发生发展中的作用

张阳; 李军祥; 王允亮

doi:10.3969/j.issn.1001-5256.2020.06.040

胆汁酸代谢及其受体在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.06.040

1. 北京中医药大学研究生院
2. 北京中医药大学东方医院消化内科

基金项目:

国家自然科学基金青年课题(81503407)；北京中医药大学科研创新岐黄团队项目(2019-JYB-TD004);北京中医药大学基本科研业务费项目(2019-JYB-JS-134)；

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2020-01-08
- 出版日期: 2020-06-20

Role of bile acid metabolism and related receptors in the development and progression of nonalcoholic fatty liver disease

Graduated School of Beijing University of Chinese Medicine
Department of Gastroenterology,Dongfang Hospital,Beijing University of Chinese Medicine

Research funding:

摘要

摘要:
肠肝循环在非酒精性脂肪性肝病发病机制中扮演重要角色。胆汁酸作为肠肝循环的基础物质,在机体脂质代谢、肠道菌群调节、宿主免疫等方面发挥重要作用。总结了胆汁酸作为信号分子,激活肝、肠等组织中的胆汁酸受体,如法尼醇X受体、G蛋白偶联受体5、孕烷X受体和维生素D受体等,参与非酒精性脂肪性肝病发病机制的研究进展。认为针对以上靶点进行研究,有望研发治疗非酒精性脂肪性肝病的有效药物,但尚待进一步探索。
- 非酒精性脂肪性肝病 /
- 胆酸类 /
- 肠肝循环
Abstract:
Enterohepatic circulation plays an important role in the pathogenesis of nonalcoholic fatty liver disease( NAFLD). Bile acid is the basic substance of enterohepatic circulation and plays an important role in lipid metabolism,intestinal flora regulation,and host immunity. This article summarizes the research advances in bile acid which acts as a signal molecule to activate bile acid receptors in the liver and intestine,such as farnesoid X receptor,G protein-coupled receptor 5,pregnane X receptor,and vitamin D receptor,and is thus involved in the pathogenesis of NAFLD. It is expected to develop effective drugs for the treatment of NALFD based on the above targets,but there is still a need for further exploration.
- non-alcoholic fatty liver disease /
- cholic acids /
- enterohepatic circulation

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