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外周血清5-羟色胺与血小板水平对肝细胞癌患者预后的影响

王志鑫 李姚 周留馨 任利 曲凯 苗润 侯立朝 王海久 刘昌 樊海宁

潘岩, 刘鲁明, 陈震, 孟志强, 林钧华, 陈颢, 沈晔华. 中西医结合治疗190例老年胰腺癌的预后分析[J]. 临床肝胆病杂志, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
引用本文: 潘岩, 刘鲁明, 陈震, 孟志强, 林钧华, 陈颢, 沈晔华. 中西医结合治疗190例老年胰腺癌的预后分析[J]. 临床肝胆病杂志, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
Pan Yan, Liu LuMing, Chen Zhen, Meng ZhiQiang, Lin JunHua, Chen Hao, Shen YeHua. Prognostic analysis of 190 elderly patients with pancreatic cancer treated by integrated traditional Chinese and Western medicine therapy[J]. J Clin Hepatol, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
Citation: Pan Yan, Liu LuMing, Chen Zhen, Meng ZhiQiang, Lin JunHua, Chen Hao, Shen YeHua. Prognostic analysis of 190 elderly patients with pancreatic cancer treated by integrated traditional Chinese and Western medicine therapy[J]. J Clin Hepatol, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.

外周血清5-羟色胺与血小板水平对肝细胞癌患者预后的影响

DOI: 10.3969/j.issn.1001-5256.2020.07.017
基金项目: 

青海省自然科学基金青年项目(2017-ZJ-963Q); 青海大学中青年科研基金项目(2016-QYY-4); 2017年青海“高端创新人才千人计划”(培养拔尖人才项目); 

详细信息
  • 中图分类号: R735.7

Influence of 5-hydroxytryptamine and platelet count in peripheral blood on the prognosis of patients with hepatocellular carcinoma

Research funding: 

 

  • 摘要:

    目的探究血小板及其内源性5-羟色胺(5-HT)与肝细胞癌患者预后的关系。方法回顾性分析西安交通大学第一附属医院2004年1月-2012年12月治疗的210例肝细胞癌患者资料,并根据血小板计数高低分为低血小板组(n=129)与高血小板组(n=81),对比组间差异因素并进行预后分析。收集20例住院复发/转移肝癌患者及32例非复发/转移肝癌患者外周血标本,用ELISA法检测患者外周血清5-HT水平,血小板聚集仪检测血小板聚集率。血小板计数与肝癌临床病理因素之间的关系分析采用χ2检验;不同肝癌分组患者的外周血小板计数、聚集率及外周血5-HT水平比较采用Mann-Whitney U检验。血小板计数与生存期相关性以及5-HT水平与血小板计数、聚集率相关性分析采用一元线性回归。生存率及复发率分析采用Kaplan-Meier法,组间比较采用log-rank检验,影响肝癌患者预后因素分析使用Cox回归分析。结果不同血小板水平患者的年龄(χ2=32. 304,P=0. 044)、肿瘤大小(χ2=35. 201,P=0. 001)、肿瘤数目(χ2=31. 304,P=0. 032)、Child分级(χ2=3...

     

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