多聚免疫球蛋白受体在肝细胞癌发病及诊治中的作用

张媛; 陈晓蓉; 杨宗国

doi:10.3969/j.issn.1001-5256.2020.07.043

多聚免疫球蛋白受体在肝细胞癌发病及诊治中的作用

DOI: 10.3969/j.issn.1001-5256.2020.07.043

1. 复旦大学附属公共卫生临床中心
2. 上海市公共卫生临床中心

基金项目:

国家自然科学基金项目(81803901)；上海市科委青年科技英才扬帆计划(17YF1416000)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2020-07-20

Role of polymeric immunoglobulin receptor in the metastasis,growth,diagnosis,and treatment of hepatocellular carcinoma

1, 2. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China

Research funding:

摘要

摘要:
肝脏慢性炎症是促进肝细胞癌发展的危险因素,在病毒感染的情况下,Fc受体信号加强也会进一步加重炎症反应,参与癌变的过程。多聚免疫球蛋白受体(pIgR)不仅在抗感染免疫第一线发挥至关重要的作用,在早期肝细胞癌的肿瘤转移和肿瘤生长中也发挥促进作用。将p IgR鉴定为早期肝癌患者转移潜能的预测指标可以有助于早期患者的分层和制订治疗决策,对改善患者预后具有积极意义。靶向抑制pIgR/Yes信号级联反应作为一种潜在的治疗方案可能会为控制肿瘤大小以允许切除或移植提供更多的治疗选择。
- 癌,肝细胞 /
- 多聚免疫球蛋白受体 /
- 受体,Fc /
- 肿瘤转移 /
- 生长 /
- 诊断
Abstract:
Chronic inflammation of the liver is a risk factor that promotes the progression of hepatocellular carcinoma,and in the presence of viral infection,enhanced Fc receptor signal will further aggravate inflammatory response and participate in the process of canceration. Polymeric immunoglobulin receptor( pIgR) not only plays a critical role in first-line anti-infection immunity,but also promotes the metastasis and growth of early-stage hepatocellular carcinoma. Identifying pIgR as a predictive index for metastatic potential in patients with early-stage liver cancer can help to promote the stratification and treatment decisions for such patients,which has a positive significance in improving patient prognosis. Targeted inhibition of the pIgR/Yes signal cascade as a potential treatment option may provide more treatment options for controlling tumor size to allow resection or transplantation.
- carcinoma,hepatocellular /
- polymeric immunoglobulin receptor /
- receptors,Fc /
- neoplasm metastasis /
- growth /
- diagnosis

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参考文献(30)

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