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Mechanism of action of microRNA-27a in the development and progression of liver diseases
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摘要:
microRNA（miRNA）是小分子非编码RNA,可通过转录后基因表达的调控来调节多种生理和病理功能。越来越多的证据表明miRNA-27a在肝病的发展和发病机制中发挥了作用。通过总结相关研究,介绍了miRNA-27a在脂肪肝、肝炎、肝纤维化及肝癌等多种肝脏疾病中作用的研究进展,也分析了miRNA-27a在肝脏再生中的作用以及作为生物标志物的潜能。通过对miRNA-27a在慢性肝病发生发展中相关机制的总结归纳,可以对后续的相关研究提供相应的借鉴,对探索慢性肝病新的治疗思路提供更多的可能性。
Abstract:microRNAs( miRNAs) are low-molecular-weight non-coding RNAs that regulate various physiological and pathological functions through the regulation of gene expression at the post-transcriptional level. More and more evidence has shown that microRNA-27 a( miRNA-27 a) plays a role in the development and pathogenesis of liver diseases. By reviewing and updating related studies,this article introduces the research advances in the role of miRNA-27 a in various liver diseases including fatty liver disease,hepatitis,hepatic fibrosis,and liver cancer and analyzes the role of miRNA-27 a in liver regeneration and its potential as a biomarker,so as to provide a reference for future studies and more possibilities for new treatment ideas for chronic hepatic diseases.
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Key words:
- micrornas /
- fatty liver /
- hepatitis /
- liver cirrhosis /
- liver neoplasms /
- liver regeneration
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