肝脏淋巴管新生在肝纤维化进展中的作用

石纳; 陈修利; 吴昊; 毛靖伟

doi:10.3969/j.issn.1001-5256.2020.09.038

肝脏淋巴管新生在肝纤维化进展中的作用

DOI: 10.3969/j.issn.1001-5256.2020.09.038

大连医科大学附属第一医院消化内科

基金项目:

国家自然科学基金资助项目(81500402)；辽宁省自然科学基金资助项目(20180530055)；

详细信息

中图分类号: R575.2
计量
- 文章访问数: 762
- HTML全文浏览量: 24
- PDF下载量: 111
- 被引次数: 0
出版历程
- 出版日期: 2020-09-20

Role of hepatic lymphangiogenesis in the progression of liver fibrosis

Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University

Research funding:

摘要

摘要:
肝纤维化可进展为肝硬化、终末期肝病而导致预后不良。除与病理性血管生成和肝血窦重塑相关外,肝脏淋巴管新生在肝纤维化的进展中也起重要作用。简述了淋巴管标志物及其在肝脏中的表达,叙述了淋巴管新生在肝纤维化中的作用,归纳了肝脏巨噬细胞即Kupffer细胞和淋巴管内皮细胞在肝脏淋巴管新生中的作用,提出淋巴管新生可能成为干预肝纤维化的潜在靶点,对早期治疗及逆转肝纤维化、预防肝硬化及终末期肝病的发生具有重要作用。
- 肝硬化 /
- 淋巴管 /
- 枯否细胞
Abstract:
Liver fibrosis can progress to liver cirrhosis and end-stage liver disease,which may lead to poor prognosis. In addition to pathological angiogenesis and hepatic sinusoid remodeling,hepatic lymphangiogenesis also plays an important role in the progression of liver fibrosis. This article briefly describes lymphatic vessel markers and their expression in the liver,introduces the role of lymphangiogenesis in liver fibrosis,and reviews the role of liver macrophages( Kupffer cells) and lymphatic endothelial cells in lymphangiogenesis. It is pointed out lymphangiogenesis may become a potential target for the intervention of liver fibrosis,which plays an important role in the early treatment and reversal of liver fibrosis and the prevention of liver cirrhosis and end-stage liver disease.
- liver cirrhosis /
- lymphatic vessels /
- Kupffer cells

HTML全文

参考文献(37)

[1] DUARTE S,BABER J,FUJII T,et al. Matrix metalloproteinases in liver injury,repair and fibrosis[J]. Matrix Biol,2015,44-46:147-156.

[2] SRIVASTAVA A,SHUKLA V,TIWARI D,et al. Targeted therapy of chronic liver diseases with the inhibitors of angiogenesis[J]. Biomed Pharmacother,2018,105:256-266.

[3] RIBERA J,PAUTA M,MELGAR-LESMES P,et al. Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats[J]. Gut,2013,62(1):138-145.

[4] JACKSON DG. Leucocyte trafficking via the lymphatic vasculature-mechanisms and consequences[J]. Front Immunol,2019,10:471.

[5] ZHENG M,KIMURA S,NIO-KOBAYASHI J,et al. The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system?(RES)[J].Biomed Res,2016,37(3):187-198.

[6] TANAKA M,IWAKIRI Y. The hepatic lymphatic vascular system:Structure, function, markers, and lymphangiogenesis[J]. Cell Mol Gastroenterol Hepatol,2016,2(6):733-749.

[7] KITAGAWA K,NAKAJIMA G,KURAMOCHI H,et al. Lymphatic vessel endothelial hyaluronan receptor-1 is a novel prognostic indicator for human hepatocellular carcinoma[J].Mol Clin Oncol,2013,1(6):1039-1048.

[8] ARIMOTO J,IKURA Y,SUEKANE T,et al. Expression of LYVE-1 in sinusoidal endothelium is reduced in chronically inflamed human livers[J]. J Gastroenterol,2010,45(3):317-325.

[9] ELSIR T,SMITS A,LINDSTRM MS,et al. Transcription factor PROX1:Its role in development and cancer[J]. Cancer Metastasis Rev,2012,31(3-4):793-805.

[10] PARK KJ,CHO SB,PARK YL,et al. Prospero homeobox 1mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis[J]. Gastric Cancer,2017,20(1):104-115.

[11] DUDAS J,MANSUROGLU T,MORICONI F,et al. Altered regulation of Prox1-gene-expression in liver tumors[J].BMC Cancer,2008,8:92.

[12] SHIMODA M,TAKAHASHI M,YOSHIMOTO T,et al. A homeobox protein,prox1,is involved in the differentiation,proliferation,and prognosis in hepatocellular carcinoma[J]. Clin Cancer Res,2006,12(20 Pt 1):6005-6011.

[13] WEBER E,SOZIO F,BORGHINI A,et al. Pulmonary lymphatic vessel morphology:A review[J]. Ann Anat,2018,218:110-117.

[14] SUZUKI-INOUE K. CLEC-2/podoplanin and thromboinflammation[J]. Blood,2017,129(14):1896-1898.

[15] SCHACHT V,RAMIREZ MI,HONG YK,et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema[J]. EMBO J,2003,22(14):3546-3556.

[16] LINK A,HARDIE DL,FAVRE S,et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans[J]. Am J Pathol,2011,178(4):1662-1675.

[17] HSU MC,PAN MR,HUNG WC. Two Birds,one stone:Double hits on tumor growth and lymphangiogenesis by targeting vascular endothelial growth factor receptor 3[J]. Cells,2019,8(3):270.

[18] GAUDIO E,BARBARO B,ALVARO D,et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism[J]. Gastroenterology,2006,130(4):1270-1282.

[19] FRANCHITTO A,ONORI P,RENZI A,et al. Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases[J]. Hepatobiliary Surg Nutr,2013,2(2):68-77.

[20] WANG J,HUANG Y,ZHANG J,et al. NRP-2 in tumor lymphangiogenesis and lymphatic metastasis[J]. Cancer Lett,2018,418:176-184.

[21] KIM Y,HWANG SD,LIM JH,et al. Attenuated lymphatic proliferation ameliorates diabetic nephropathy and high-fat dietinduced renal lipotoxicity[J]. Sci Rep,2019,9(1):1994.

[22] SYED SN,JUNG M,WEIGERT A,et al. S1P provokes tumor lymphangiogenesis via macrophage-derived mediators such as IL-1βor Lipocalin-2[J]. Mediators Inflamm,2017,2017:7510496.

[23] KINASHI H,ITO Y,SUN T,et al. Roles of the TGF-β-VEGFC pathway in fibrosis-related lymphangiogenesis[J]. Int J Mol Sci,2018,19(9):2487.

[24] NAKAMOTO S,ITO Y,NISHIZAWA N,et al. Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia-reperfusion injury[J]. Angiogenesis,2020,23(3):395-410.

[25] OHTANI O,OHTANI Y. Lymph circulation in the liver[J]. Anat Rec(Hoboken),2008,291(6):643-652.

[26] TAMBURINI B,FINLON JM,GILLEN AE,et al. Chronic liver disease in humans causes expansion and differentiation of liver lymphatic endothelial cells[J]. Front Immunol,2019,10:1036.

[27] CORPECHOT C,BARBU V,WENDUM D,et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis[J].Hepatology,2002,35(5):1010-1021.

[28] DA SILVA MEIRELLES L,MARSON RF,SOLARI M,et al. Are liver pericytes just precursors of myofibroblasts in hepatic diseases? Insights from the crosstalk between perivascular and inflammatory cells in liver injury and repair[J]. Cells,2020,9(1):188.

[29] SUN YY,LI XF,MENG XM,et al. Macrophage phenotype in liver injury and repair[J]. Scand J Immunol,2017,85(3):166-174.

[30] GUILLOT A,TACKE F. Liver macrophages:Old dogmas and new insights[J]. Hepatol Commun,2019,3(6):730-743.

[31] CHENG MX,LI JZ,CHEN Y,et al. VEGF-C attenuates ischemia reperfusion injury of liver graft in rats[J]. Transpl Immunol,2019,54:59-64.

[32] BURCHILL MA,GOLDBERG AR,TAMBURINI B. Emerging roles for lymphatics in chronic liver disease[J]. Front Physiol,2019,10:1579.

[33] ALLAIRE M,RAUTOU PE,CODOGNO P,et al. Autophagy in liver diseases:Time for translation?[J]. J Hepatol,2019,70(5):985-998.

[34] CORLISS BA,AZIMI MS,MUNSON JM,et al. Macrophages:An inflammatory link between angiogenesis and lymphangiogenesis[J]. Microcirculation,2016,23(2):95-121.

[35] LUKACS-KORNEK V. The role of lymphatic endothelial cells in liver injury and tumor development[J]. Front Immunol,2016,7:548.

[36] TANAKA M,IWAKIRI Y. Lymphatics in the liver[J]. Curr Opin Immunol,2018,53:137-142.

[37] XU H,ZHOU Y,LU C,et al. Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting Rho A signaling pathway[J].Lab Invest,2012,92(12):1738-1748.

施引文献

资源附件(0)

访问统计