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Regulatory effect of tumor-associated neutrophils in the development and progression of liver cancer
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摘要:
近年来肝癌的发病率仍在上升,早期诊断困难,治疗效果不好,预后差。叙述了肿瘤相关中性粒细胞参与调控肝癌肿瘤微环境的研究进展,指出其可以作为肝癌治疗的新靶点。结合肝细胞癌微环境中存在的肿瘤相关巨噬细胞、调节性T淋巴细胞和多种细胞因子等,可能会达到系统抗肿瘤的效果,为肝癌治疗带来曙光。
Abstract:The incidence rate of liver cancer keeps increasing in recent years,and this disease has difficulties in early diagnosis,poor treatment outcome,and poor prognosis. This article describes the research advances in tumor-associated neutrophils involved in the regulation of liver tumor microenvironment and points out that they can be used as a new target for the treatment of liver cancer. Combined with tumor-associated macrophages, regulatory T cells, and various cytokines in liver tumor microenvironment, tumor-associated neutrophils can achieve a systemic anti-tumor effect and thus bring hopes to the treatment of liver cancer.
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Key words:
- liver neoplasms /
- tumor-associated neutrophils /
- tumor microenvironment
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