Research advances of portal vein thrombosis in nonalcoholic fatty liver disease
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摘要: 非酒精性脂肪性肝病(NAFLD)作为我国第一大慢性肝病,其肝外疾病[包括心血管疾病、门静脉血栓(PVT)等]的发病率和病死率不断增加。NAFLD并发PVT的机制与传统肝硬化有明显区别。从三级凝血障碍角度入手,从三个不同等级且阶梯式地阐述了NAFLD并发PVT的发病机制,描述了运动预防和治疗NAFLD发生PVT的全新观念,为NAFLD并发PVT的肝移植受者提出了技术挑战,对提高患者预后和生存质量有重要的意义。Abstract: Nonalcoholic fatty liver disease( NAFLD) is the most important chronic liver disease in China,with increasing morbidity and mortality rates of extrahepatic diseases such as cardiovascular diseases and portal vein thrombosis( PVT). NAFLD complicated by PVT has a different mechanism from liver cirrhosis. Starting from grade Ⅲ coagulation disorder,this article elaborates on the pathogenesis of NAFLD complicated by PVT from three different grades and in steps and describes the new concept of sports and exercise in the prevention and treatment of NAFLD complicated by PVT,which brings a technical challenge for liver transplantation recipients with NAFLD complicated by PVT and is of great significance to improve the prognosis and quality of life of patients.
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