辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用

唐光俊; 游晶; 刘怀鄂; 彭玉娟

doi:10.3969/j.issn.1001-5256.2021.02.035

辅助性T淋巴细胞17/调节性T淋巴细胞比值失衡在HBV相关肝脏疾病进展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.02.035

昆明医科大学第一附属医院感染性疾病和肝病科，昆明 650032

基金项目:

国家自然科学基金 (81760111);

国家自然科学基金 (81760617);

云南省应用基础研究项目 (2017FE468〔-033〕)

作者贡献声明:唐光俊负责文献阅读，撰写论文；刘怀鄂、彭玉娟负责提供意见并修改；游晶负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
唐光俊(1995—)，男，主要从事肝病临床基础研究

通信作者:
游晶，jingyoukm@126.com

中图分类号: R512.62
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-21
- 录用日期: 2020-09-04
- 出版日期: 2021-02-20

Role of T helper 17 cell/regulatory T cell imbalance in the progression of HBV-related liver diseases

Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

摘要

摘要: 慢性乙型肝炎患者肝脏损害多发生在免疫介导作用下，考虑病毒感染和免疫反应的相互作用是疾病病情进展的重要原因。慢性乙型肝炎可发展至肝纤维化、肝硬化甚至肝细胞癌。回顾了辅助性T淋巴细胞17(Th17)与调节性T淋巴细胞(Treg)的发现起源，叙述了二者自身特性，同时阐述了在维持免疫系统稳定过程中二者所起的作用及作用机制；详细分析了细胞失衡在慢性乙型肝炎、肝纤维化、肝硬化、肝细胞癌等各个阶段中的作用，指出Th17/Treg失衡会促使HBV相关肝脏疾病病情加重。
- 乙型肝炎病毒 /
- Th17细胞 /
- T淋巴细胞, 调节性
Abstract: Patients with chronic hepatitis B (CHB) often have immune-mediated liver injury, and it is considered that the interaction between viral infection and immune response is an important cause of disease progression. CHB can progress to liver fibrosis, liver cirrhosis, and even hepatocellular carcinoma (HCC). This article reviews the discovery of T helper 17 (Th17) cells and regulatory T (Treg) cells, describes their own features, and elaborates on their role and mechanism of action in maintaining the stability of the immune system. This article also analyzes the role of Th17/Treg cell imbalance in CHB, liver fibrosis, liver cirrhosis, and HCC and points out that Th17/Treg cell imbalance may promote the aggravation of HBV-related liver diseases.
- Hepatitis B Virus /
- Th17 Cells /
- T-Lymphocytes, Helper-Inducers

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参考文献(48)

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