胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制

陈研焰; 蓝艳梅; 王明刚; 毛德文

doi:10.3969/j.issn.1001-5256.2021.02.049

胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.02.049

1.
湖南中医药高等专科学校基础医学部，湖南株洲 412000
2a.
广西中医药大学第一附属医院科研部，南宁 530023
2b.
广西中医药大学第一附属医院肝病科，南宁 530023

基金项目:

国家自然科学基金 (81960841);

国家自然科学基金 (81774236);

国家自然科学基金 (81704021);

国家自然科学基金 (81760844);

广西自然科学基金创新研究团队项目 (2018GXNSFGA281002);

广西自然科学基金 (2017GXNSFBA198200);

广西自然科学基金 (2018GXNSFAA281047);

广西高校中青年教师基础能力提升项目 (2019KY0318);

广西高校中青年教师基础能力提升项目 (XP019012)

作者贡献声明：陈研焰负责资料分析，撰写论文；蓝艳梅、王明刚负责课题设计，收集数据，修改论文；毛德文负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
陈研焰(1990—)，女，主要从事中医药防治肝病研究

通信作者:
毛德文，mdwboshi2005@163.com

中图分类号: R575
计量
- 文章访问数: 674
- HTML全文浏览量: 121
- PDF下载量: 47
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-16
- 录用日期: 2020-08-17
- 出版日期: 2021-02-20

Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration

1.
Department of Basic Medicine, Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China
2a.
Department of Scientific Research, Nanning 530023, China
2b.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

摘要

摘要: 肝衰竭是常见的内科危重症，短时间内肝细胞大面积坏死而超过肝细胞再生能力导致该病病死率极高，促进有效肝再生是拮抗肝衰竭的关键。近年来发现胆汁酸、法尼醇核受体R、肠道微生态在肝衰竭和肝再生机制中发挥重要作用。现就胆汁酸、法尼醇核受体R、肠道微生态三者之间的相关性，及三者对肝衰竭和肝再生机制的作用方面进行综述，为临床肝衰竭的治疗提供新思路。
- 肝功能衰竭 /
- 肝再生 /
- 胆汁酸 /
- 法尼醇核受体R /
- 胃肠道微生物组
Abstract: Liver failure is a common critical medical disease, and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate. Promotion of effective liver regeneration is the key to antagonizing liver failure. Recent studies have shown that bile acid, farnesoid X receptor (FXR), and intestinal microecology play an important role in liver failure and liver regeneration. This article reviews the association between bile acid, FXR, and intestinal microecology and their role in liver failure and liver regeneration, so as to provide new ideas for the treatment of liver failure in clinical practice.
- Liver Failure /
- Liver Regeneration /
- Bile Acid /
- Farnesol Receptor R /
- Gastrointestinal Microbiome

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参考文献(59)

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