肝上皮样血管内皮瘤所致黄疸、门静脉高压1例报告

张瑞华; 秦婷婷; 邵玥明; 张雨; 王阳; 温晓玉

doi:10.3969/j.issn.1001-5256.2021.07.036

肝上皮样血管内皮瘤所致黄疸、门静脉高压1例报告

DOI: 10.3969/j.issn.1001-5256.2021.07.036

吉林大学第一医院肝胆胰内科，长春 130021

基金项目:

吉林省科技计划项目基金 (20190201065JC)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张瑞华负责课题设计，资料分析，撰写论文；秦婷婷、邵玥明、张雨参与收集及分析数据；王阳指导撰写文章并修改论文；温晓玉负责拟定写作思路并最后定稿。

详细信息

通信作者:
王阳，wang19900403@163.com

温晓玉，xywen@jlu.edu.cn

中图分类号: R732.2
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- 文章访问数: 657
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- 被引次数: 0
出版历程
- 收稿日期: 2020-11-10
- 录用日期: 2021-01-15
- 出版日期: 2021-07-20

Jaundice and portal hypertension caused by hepatic epithelioid hemangioendothelioma: A case report

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

Foundation of Science and Technology Commission of Jilin Province (20190201065JC)

摘要

- 血管内皮瘤, 上皮样 /
- 高血压, 门静脉 /
- 黄疸
- Hemangioendothelioma, Epithelioid /
- Hypertension, Portal /
- Jaundice

HTML全文

图 1 肝CT扫描结果

注：a，矢状面；b，冠状面。肝体积稍大，表面不光滑，肝叶比例不协调，肝门肝裂增宽，肝实质密度不均。箭头指示为肝内低密度影。

下载: 全尺寸图片幻灯片

图 2 肝组织病理切片

注：a，切片内主要为肿瘤组织，其间可见残留的汇管区成分与肝细胞片团，瘤细胞大部分成梭形，散在，部分形成不规则腔隙，沿肝窦浸润并破坏临近肝实质(HE染色，×40)；b，CD34免疫组化染色阳性(×400)；c，CD34免疫组化+PAS染色阳性(×400)；d，ERG染色阳性(×400)。

下载: 全尺寸图片幻灯片

参考文献(18)

[1]	TRESKA V, DAUM O, SVAJDLER M, et al. Hepatic epithelioid hemangioendothelioma - a rare tumor and diagnostic dilemma[J]. In Vivo, 2017, 31(4): 763-767. DOI: 10.21873/invivo.11128.
[2]	WEISS SW, ENZINGER FM. Epithelioid hemangioendothelioma: A vascular tumor often mistaken for a carcinoma[J]. Cancer, 1982, 50(5): 970-981. DOI: 10.1002/1097-0142(19820901)50:5<970::aid-cncr2820500527>3.0.co;2-z.
[3]	ISHAK KG, SESTERHENN IA, GOODMAN ZD, et al. Epithelioid hemangioendothelioma of the liver: A clinicopathologic and follow-up study of 32 cases[J]. Hum Pathol, 1984, 15(9): 839-852. DOI: 10.1016/s0046-8177(84)80145-8.
[4]	ZHANG QB, TAO YF, LI RD, et al. Orthotopic liver transplantation for treatment of hepatic epithelioid hemangioendothelioma: report of two cases and literature review[J]. Organ Transplantation, 2017, 8(1): 59-65.
[5]	BOUDOUSQUIE AC, LAWCE HJ, SHERMAN R, et al. Complex translocation[7;22] identified in an epithelioid hemangioendothelioma[J]. Cancer Genet Cytogenet, 1996, 92(2): 116-121. DOI: 10.1016/s0165-4608(96)00175-6.
[6]	MENDLICK MR, NELSON M, PICKERING D, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma[J]. Am J Surg Pathol, 2001, 25(5): 684-687. DOI: 10.1097/00000478-200105000-00019.
[7]	温绍君, 刘洁琳. 血管内皮细胞功能研究概况[J]. 生殖医学杂志, 2005, 14(5): 310-313. DOI: 10.3969/j.issn.1004-3845.2005.05.017.
[8]	杨香瑜, 张韶辉, 陈露, 等. 来曲唑致重度脂肪肝1例并文献复习[J]. 中国新药与临床杂志, 2020, 39(1): 61-62. DOI: 10.14109/j.cnki.xyylc.2020.01.13.
[9]	LERUT J, IESARI S. Vascular tumours of the liver: A particular story[J]. Transl Gastroenterol Hepatol, 2018, 3: 62. DOI: 10.21037/tgh.2018.09.02.
[10]	YANG JQ, SHI HC, LI HM, et al. Diagnostic value of ¹⁸F-FDG PET/CT for hepatic epithelioid hemangioendothelioma[J]. Chin J Nucl Med Mol Imaging, 2017, 37(11): 700-704. DOI: 10.3760/cma.j.issn.2095-2848.2017.11.006. 杨吉琴, 石洪成, 李艳梅, 等. ¹⁸F-FDG PET/CT对肝上皮样血管内皮瘤的诊断价值[J]. 中华核医学与分子影像杂志, 2017, 37(11): 700-704. DOI: 10.3760/cma.j.issn.2095-2848.2017.11.006.
[11]	ZHANG LY, WU KL, LI J, et al. Invasive primary hepatic epithelioid hemangioendothelioma: A case report[J]. J Clin Hepatol, 2020, 36(7): 1605-1607. DOI: 10.3969/j.issn.1001-5256.2020.07.033. 张丽媛, 吴坤亮, 李君, 等. 侵袭性原发性肝上皮样血管内皮瘤1例报告[J]. 临床肝胆病杂志, 2020, 36(7): 1605-1607. DOI: 10.3969/j.issn.1001-5256.2020.07.033.
[12]	PALLOTTI MC, NANNINI M, AGOSTINELLI C, et al. Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma[J]. World J Gastroenterol, 2014, 20(22): 7049-7054. DOI: 10.3748/wjg.v20.i22.7049.
[13]	KAWAOKA T, AIKATA H, HYOGO H, et al. Comparison of hepatic arterial infusion chemotherapy versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma[J]. J Dig Dis, 2015, 16(9): 505-512. DOI: 10.1111/1751-2980.12267.
[14]	GROTZ TE, NAGORNEY D, DONOHUE J, et al. Hepatic epithelioid haemangioendothelioma: Is transplantation the only treatment option?[J]. HPB (Oxford), 2010, 12(8): 546-553. DOI: 10.1111/j.1477-2574.2010.00213.x.
[15]	LI X, GUO XL, JI HF, et al. Epithelioid hemangioendothelioma of the liver: A case report [J]. J Clin Hepatol, 2016, 32(7): 1396-1397. DOI: 10.3969/j.issn.1001-5256.2016.07.041. 李旭, 郭晓林, 季慧范, 等. 肝上皮样血管内皮瘤1例报告[J]. 临床肝胆病杂志, 2016, 32(7): 1396-1397. DOI: 10.3969/j. issn.1001-5256.2016.07.041.
[16]	WANG FJ, LIU KY, QI Y, et al. A case of hepatic epithelioid hemangioendothelioma[J]. J Clin Hepatol, 2015, 31(6): 961-962. DOI: 10.3969/j.issn.1001-5256.2015.06.032. 王丰姣, 刘开艳, 齐月, 等. 肝上皮样血管内皮瘤1例报告[J]. 临床肝胆病杂志, 2015, 31(6): 961-962. DOI: 10.3969/j.issn.1001-5256.2015.06.032.
[17]	LU W, ZHANG R, JIANG HL, et al. One case of hepatic epithelioid hemangioendothelioma[J]. J Clin Hepatol, 2015, 31(8): 1330-1331. DOI: 10.3969/j.issn.1001-5256.2015.08.038. 卢旺, 张睿, 姜红丽, 等. 肝上皮样血管内皮细胞瘤1例报告[J]. 临床肝胆病杂志, 2015, 31(8): 1330-1331. DOI: 10.3969/j.issn.1001-5256.2015.08.038.
[18]	ZHANG L, WANG ZF, SONG LS, et al. Transcatheter arterial chemoembolization combinedd with apatinib for the treatment of hepatic epithelioid hemangioendothelioma; A case report[J]. J Clin hepatol, 2019, 35(6): 1342-1343. DOI: 10.3969/j.issn.1001-5256.2019.06.033. 张露, 王中锋, 宋立莎, 等. 经肝动脉化疗栓塞术联合阿帕替尼治疗上皮肝样血管内皮瘤1例报告[J]. 临床肝胆病杂志, 2019, 35(6): 1342-1343. DOI: 10.3969/j.issn.1001-5256.2019.06.033.