非酒精性脂肪性肝病在研新药的进展

徐昆; 张旭; 李瑛; 胡振斌

doi:10.3969/j.issn.1001-5256.2021.07.047

非酒精性脂肪性肝病在研新药的进展

DOI: 10.3969/j.issn.1001-5256.2021.07.047

徐昆¹,
张旭¹,
李瑛¹,
胡振斌^2, ,

1.
广西中医药大学研究生院，南宁 530222
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家十三五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项基金 (2018ZX10725505-002)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：胡振斌负责课题设计, 修改论文, 指导撰写文章并最后定稿; 徐昆负责拟定写作思路, 资料分析, 撰写论文; 张旭、李瑛负责收集数据。

详细信息

通信作者:
胡振斌，huzhenbin123@163.com

中图分类号: R575.5
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- 被引次数: 0
出版历程
- 收稿日期: 2020-11-23
- 录用日期: 2021-01-11
- 出版日期: 2021-07-20

Advances in investigational new drugs for nonalcoholic fatty liver disease

Kun XU¹,
Xu ZHANG¹,
Ying LI¹,
Zhenbin HU^{2
, ,}

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2.
First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

The National Thirteenth Five-Year Plan"Prevention and Treatment of Major Infectious Diseases such as AIDS and Viral Hepatitis" Science and Technology Major Special Fund Project (2018ZX10725505-002)

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是全世界最常见的肝脏疾病，与肥胖、胰岛素抵抗和其他代谢性疾病密切相关。目前尚无批准用于治疗的药物，常规的生活方式管理也难以对疾病产生积极的影响。对目前在研的代谢调节剂、抗炎抗氧化剂及抗纤维化剂等NAFLD治疗药物进行了综述，归纳总结了其临床研究结果，为NAFLD的临床治疗及药物研发提供新思路。
- 非酒精性脂肪性肝病 /
- 药物, 临床试用 /
- 抗氧化剂
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is closely associated with obesity, insulin resistance, and other metabolic diseases. There are currently no drugs approved for treatment, and routine lifestyle management can hardly have a positive impact on this disease. This article reviews the investigational new drugs for NAFLD, including metabolic regulators, anti-inflammatory antioxidants, and anti-fibrosis agents, and summarizes the results of their clinical studies, so as to provide new ideas for the clinical treatment of NAFLD and the and development of related drugs.
- Nonalcoholic Fatty Liver Disease /
- Drugs, Investigational /
- Antioxidants

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参考文献(43)

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