雌激素缺乏对绝经后女性非酒精性脂肪性肝病的影响

赵晨露; 赵文霞

doi:10.3969/j.issn.1001-5256.2021.07.049

雌激素缺乏对绝经后女性非酒精性脂肪性肝病的影响

DOI: 10.3969/j.issn.1001-5256.2021.07.049

赵晨露¹,
赵文霞^2, ,

1.
河南中医药大学第一临床医学院, 郑州 450046
2.
河南中医药大学第一附属医院脾胃肝胆科, 郑州 450000

基金项目:

国家自然科学基金面上项目 (81473651);

河南省科技攻关计划项目 (202102310495)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：赵晨露负责撰写论文; 赵文霞负责指导撰写文章, 修改论文。

详细信息

通信作者:
赵文霞, zhao_wenxia@163.com

中图分类号: R575.5
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- 文章访问数: 588
- HTML全文浏览量: 446
- PDF下载量: 36
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-18
- 录用日期: 2021-01-05
- 出版日期: 2021-07-20

Influence of estrogen deficiency on metabolic associated fatty liver disease in postmenopausal women

Chenlu ZHAO¹,
Wenxia ZHAO^{2
, ,}

1.
The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China(General Program) (81473651);

Science and Technology Key Project of Henan Province (202102310495)

摘要

摘要: 流行病学数据显示, 绝经后女性非酒精性脂肪性肝病(NAFLD)的发病率显著高于绝经前女性和同龄期男性。针对这一临床现象, 重点从胰岛素抵抗、肝脂质代谢、肝纤维化和肠道菌群四个方面总结了雌激素缺乏对绝经后女性NAFLD潜在的影响机制, 为绝经后女性NAFLD的早期临床防治提供参考。
- 雌激素 /
- 非酒精性脂肪性肝病 /
- 绝经后期
Abstract: Epidemiological data have shown that postmenopausal women have a significantly higher incidence rate of metabolic associated fatty liver disease (MAFLD) than premenopausal women and men of the same age. Aiming at this phenomenon, this article summarizes the potential influence mechanism of estrogen deficiency on MAFLD in postmenopausal women from the four aspects of insulin resistance, liver lipid metabolism, liver fibrosis, and intestinal flora, so as to provide a reference for the early clinical prevention and treatment of MAFLD in postmenopausal women.
- Estrogen /
- Non-alcoholic Liver Disease /
- Postmenopause

HTML全文

图 1 各年龄段NAFLD患病人群中的男女比例

下载: 全尺寸图片幻灯片

图 2 雌激素缺乏对绝经后女性NAFLD的作用机制

下载: 全尺寸图片幻灯片

参考文献(47)

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