自噬与非酒精性脂肪性肝病调控相关因子的关系

赵佳鹤; 马欣雨; 徐敬娅; 段婷婷; 张春蕾; 李宝龙

doi:10.3969/j.issn.1001-5256.2021.07.050

自噬与非酒精性脂肪性肝病调控相关因子的关系

DOI: 10.3969/j.issn.1001-5256.2021.07.050

1.
黑龙江中医药大学药物安全性评价中心, 哈尔滨 150040
2.
黑龙江中医药大学佳木斯学院, 黑龙江佳木斯 154000

基金项目:

国家自然科学基金面上项目 (81573135);

黑龙江中医药大学优秀青年学术带头人支持计划项目

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：李宝龙、赵佳鹤负责课题设计, 资料分析, 撰写论文, 修改论文; 马欣雨、徐敬娅、段婷婷参与收集分析文献资料; 李宝龙、张春蕾负责拟定写作思路, 指导撰写文章并最后定稿。

详细信息

通信作者:
李宝龙, lbl73@163.com

中图分类号: R575.5
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- 文章访问数: 781
- HTML全文浏览量: 123
- PDF下载量: 70
- 被引次数: 0
出版历程
- 收稿日期: 2020-11-23
- 录用日期: 2021-01-05
- 出版日期: 2021-07-20

Research advances in related factors for autophagy in the regulation of nonalcoholic fatty liver disease

1.
Center for Safety Evaluation of Drugs, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2.
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154000, China

Research funding:

National Natural Science Foundation of China (General Program) (81573135);

Heilongjiang University of Chinese Medicine Outstanding Young Academic Leader Support Program Project

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)是一种常见疾病, 病理表现为肝细胞内脂肪滴大量蓄积。NAFLD不仅成因复杂, 还可诱发心血管疾病、糖尿病等, 然而目前尚无有效的治疗手段和专门的治疗药物。自噬在真核生物中普遍存在, 具有维持细胞内稳态的作用。自噬选择性降解细胞中脂质的机制称为脂噬, 该机制为缓解因脂质蓄积引起的疾病提供了新思路。从NAFLD发生发展、脂肪滴降解过程、肝脏炎症和纤维化进展相关因子入手, 探讨了自噬与NAFLD的相关性。这可能为从自噬入手治疗NAFLD提供理论基础, 并为相关药物的研发提供作用靶点。
- 自噬 /
- 非酒精性脂肪性肝病 /
- 生物因子
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a common disease characterized by the accumulation of lipid droplets (LDs) in hepatocytes. Clinical studies have shown that NAFLD not only has complex causes, but also can induce cardiovascular diseases and diabetes; however, there are still no effective therapies and specific drugs for this disease. Autophagy is ubiquitous in eukaryotes and has the function of maintaining cellular homeostasis. The mechanism of selective degradation of lipids in cells by autophagy is called lipophagy, which provides new thoughts for alleviating diseases caused by lipid accumulation. This article analyzes the association between autophagy and NAFLD in terms of the development and progression of NAFLD, the degradation of LDs, and related factors for the progression of liver inflammation and fibrosis, in order to provide a theoretical basis for the treatment of NAFLD from autophagy and provide targets for the development of related drugs.
- Autophagy /
- Non-alcoholic Fatty Liver Disease /
- Biological Factors

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