microRNA-122在肝病发生发展及诊断中的作用

陈泽山; 文彬; 丘佩容; 蓝红妮; 黄宝特; 邓鑫

doi:10.3969/j.issn.1001-5256.2021.07.052

microRNA-122在肝病发生发展及诊断中的作用

DOI: 10.3969/j.issn.1001-5256.2021.07.052

陈泽山¹,
文彬^2a,
丘佩容¹,
蓝红妮³,
黄宝特^2b,
邓鑫^2c, ,

1.
广西中医药大学研究生学院, 南宁 530001
2a.
广西中医药大学附属瑞康医院感染科, 南宁 530001
2b.
广西中医药大学附属瑞康医院科技处, 南宁 530001
2c.
广西中医药大学附属瑞康医院消化内科, 南宁 530001
3.
广西中医药大学第一附属医院内分泌科, 南宁 530001

基金项目:

国家自然科学基金 (81860790);

广西自然科学基金项目 (2017GXNSFAA198183)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：陈泽山负责课题设计, 资料分析, 撰写论文, 修改论文; 文彬、丘佩容、蓝红妮、黄宝特参与文献数据的收集及分析; 邓鑫负责拟定写作思路, 指导撰写文章并最后定稿。

详细信息

通信作者:
邓鑫, dx8849@163.com

中图分类号: R575
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- 文章访问数: 958
- HTML全文浏览量: 264
- PDF下载量: 103
- 被引次数: 0
出版历程
- 收稿日期: 2020-12-03
- 录用日期: 2020-12-25
- 出版日期: 2021-07-20

Role of microRNA-122 in the development, progression, and diagnosis of liver disease

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China
2a.
Department of Infectious Diseases, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China
2b.
Department of Science and Technology, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China
2c.
Department of Gastroenterology, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530001, China
3.
Department of Endocrinology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, China

Research funding:

National Natural Science Foundation of China (81860790);

Guangxi Natural Science Foundation of China (2017GXNSFAA198183)

摘要

摘要: microRNA(miRNA)是一类小分子非编码RNA, 转录后通过调控基因表达参与细胞增殖和凋亡等多个环节。目前越来越多的证据表明miRNA-122参与了多种肝病的发生、发展, 通过查阅相关文献报道, 总结了miRNA-122在非酒精性脂肪性肝病、肝炎、肝纤维化、肝癌等多种肝病中作用的研究进展, 同时分析了miRNA-122作为一种新型无创的生物学标志物的潜能, 为探索肝脏疾病诊疗提供参考。
- 肝疾病 /
- 微RNAs /
- 诊断
Abstract: MicroRNA is a type of small non-coding RNA that participates in multiple links such as cell proliferation and apoptosis by regulating gene expression after transcription. More and more studies have shown that microRNA-122 (miRNA-122) is involved in the development and progression of a variety of liver diseases. With reference to related reports in the literature, this article summarizes advances in the role of miRNA-122 in various liver diseases including nonalcoholic fatty liver disease, hepatitis, liver fibrosis, and liver cancer and analyzes the potential of miRNA-122 as a new noninvasive biomarker, so as to provide a reference for exploring the diagnosis and treatment of liver disease.
- Liver Diseases /
- MicroRNAs /
- Diagnosis

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参考文献(53)

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