Krüppel样因子4在肝细胞癌发生发展中的作用机制

孙菲; 苏维玮; 付艳华; 王经伟

doi:10.3969/j.issn.1001-5256.2021.10.041

Krüppel样因子4在肝细胞癌发生发展中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.10.041

山东大学齐鲁医院(青岛) 肝病科, 山东青岛 266035

基金项目:

山东大学齐鲁医院(青岛)青年项目基金 (QDKY2020QN17)

详细信息

通信作者:
王经伟，nvwangjingwei@126.com

中图分类号: R735.7
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- 文章访问数: 785
- HTML全文浏览量: 208
- PDF下载量: 40
- 被引次数: 0
出版历程
- 收稿日期: 2021-06-08
- 录用日期: 2021-07-06
- 出版日期: 2021-10-20

Mechanism of KLF4 in the development and progression of hepatocellular carcinoma

Department of Hepatology, Qilu Hospital(Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong 266035, China

Research funding:

Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University Youth Project Fund (QDKY2020QN17)

摘要

摘要: 肝细胞癌发生发展机制复杂，目前尚未完全阐明。KLF4又称为胃肠富集Krüppel样因子，具有抑癌和促癌的双重调节作用。KLF4在肝癌中发挥抑癌作用，介绍了KLF4在肝癌发展过程中的生物学功能及调控机制，研究KLF4在肝癌中作用机制有望为肝癌的靶向治疗和预后监测提供新思路。
- 癌, 肝细胞 /
- Kruppel样转录因子类 /
- 生物学功能 /
- 分子机制
Abstract: The pathogenesis of hepatocellular carcinoma is complex and has not been fully clarified. KLF4, also known as gut-enriched Kruppel-like factor (GKLF), plays the dual regulatory role of tumor suppressor and tumor promoter. KLF4 plays an anti-cancer role in liver cancer. This article introduces the biological function and regulatory mechanism of KLF4 in the progression of liver cancer, and research on the mechanism of action of KLF4 in liver cancer is expected to provide new ideas for targeted therapy and prognosis monitoring of liver cancer.
- Carcinoma, Hepatocellular /
- Kruppel-Like Transcription Factors /
- Biological Function /
- Molecular Mechanism

HTML全文

图 1 KLF4在肝癌中的作用机制

注: KLF4的表达受到DNA甲基化、microRNA、DNA损伤等因素调节。KLF4调控的下游靶基因介导了KLF4在肝癌细胞中的抑制作用。

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