昼夜节律紊乱对非酒精性脂肪性肝病及相关肝细胞癌的影响

朱金霞; 刘光伟; 杨培伟

doi:10.3969/j.issn.1001-5256.2021.10.045

昼夜节律紊乱对非酒精性脂肪性肝病及相关肝细胞癌的影响

DOI: 10.3969/j.issn.1001-5256.2021.10.045

1.
河南中医药大学第一临床医学院，郑州 450000
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金 (82003994);

河南省科技攻关项目 (182102310272);

河南省中医药科学研究专项课题 (2018JDZX109);

河南省中医药科学研究专项课题 (2019JDZX2011)

详细信息

通信作者:
刘光伟，liuguangwei1975@163.com

中图分类号: R575.5; R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-04
- 录用日期: 2021-03-30
- 出版日期: 2021-10-20

Influence of circadian rhythm disorder on nonalcoholic fatty liver disease and related hepatocellular carcinoma

1.
The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (82003994);

Science and Technology Key Project of Henan Province (182102310272);

Special Research Project of Traditional Chinese Medicine of Henan Province (2018JDZX109);

Special Research Project of Traditional Chinese Medicine of Henan Province (2019JDZX2011)

摘要

摘要: 近年来，昼夜节律紊乱对非酒精性脂肪性肝病(NAFLD)的影响逐渐受到重视，国内外研究表明，夜间轮班作业、经常熬夜等不良作息人群NAFLD相关肝细胞癌(NAFLD-HCC)发病率高于规律作息人群。总结了昼夜节律系统通过调节脂质代谢、糖代谢及肠道菌群途径影响NAFLD-HCC发病的机制研究进展，指出恢复正常的昼夜节律对延缓NAFLD-HCC发生发展有潜在的临床意义。
- 非酒精性脂肪性肝病 /
- 癌, 肝细胞 /
- 昼夜节律 /
- 昼夜节律信号肽类和蛋白质类 /
- 胃肠道微生物组
Abstract: The influence of circadian rhythm disorder on nonalcoholic fatty liver disease (NAFLD) has attracted more and more attention in recent years, and studies in China and globally have shown that individuals who work in shifts at night or often stay up late have a higher incidence rate of NAFLD-related hepatocellular carcinoma (NAFLD-HCC) than those with regular work and rest. This article summarizes the research advances in the effect of circadian rhythm system on the pathogenesis of NAFLD-HCC by regulating lipid metabolism, glucose metabolism, and intestinal flora, and it is pointed out that restoration of normal circadian rhythm has potential clinical significance in delaying the development and progression of disease.
- Non-Alcoholic Fatty Liver Disease /
- Carcinoma, Hepatocellular /
- Circadian Rhythm /
- Circadian Rhythm Signaling Peptides and Proteins /
- Gastrointestinal Microbiome

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图 1 昼夜节律反馈环路

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参考文献(46)

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