外泌体在非酒精性脂肪性肝病发生发展中的作用

徐昆; 石清兰; 胡振斌; 张旭; 李瑛

doi:10.3969/j.issn.1001-5256.2021.10.047

外泌体在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.10.047

徐昆¹,
石清兰^2, ,,
胡振斌²,
张旭¹,
李瑛¹

1.
广西中医药大学研究生院，南宁 530222
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金 (82060847);

国家自然科学基金 (81760849);

广西自然科学基金面上项目 (2020JJA140365)

详细信息

通信作者:
石清兰，bshiqinglan@163.com

中图分类号: R575.5
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- 文章访问数: 710
- HTML全文浏览量: 111
- PDF下载量: 46
- 被引次数: 0
出版历程
- 收稿日期: 2021-02-18
- 录用日期: 2021-03-15
- 出版日期: 2021-10-20

Role of exosomes in the development and progression of nonalcoholic fatty liver disease

Kun XU¹,
Qinglan SHI^{2
, ,},
Zhenbin HU²,
Xu ZHANG¹,
Ying LI¹

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2.
First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation of China (82060847);

National Natural Science Foundation of China (81760849);

General Project of Natural Science Foundation of Guangxi Province (2020JJA140365)

摘要

摘要: 随着肥胖和2型糖尿病等代谢性疾病的发病率增加，非酒精性脂肪性肝病(NAFLD)的发病率也逐年升高。NAFLD的潜在发病机制复杂，现尚未完全阐明。外泌体作为细胞间通讯的载体，在肝脏疾病的发生发展中发挥着重要作用。总结了外泌体在NAFLD发病过程中的作用机制及其对脂质代谢、胰岛素抵抗、肝脏炎症和纤维化的影响。指出了外泌体在治疗和诊断疾病方面的巨大潜力。
- 外泌体 /
- 非酒精性脂肪性肝病 /
- 肝疾病
Abstract: With the increasing incidence rates of metabolic diseases such as obesity and type 2 diabetes, the incidence rate of nonalcoholic fatty liver disease (NAFLD) has also gradually increased year by year. NAFLD has complex underlying pathogeneses which have not yet been fully clarified. As the carrier of intercellular communication, exosomes play an important role in the development and progression of liver diseases. This article summarizes the mechanism of action of exosomes in the pathogenesis of NAFLD and their effect on lipid metabolism, insulin resistance, liver inflammation, and fibrosis, and it is pointed out that exosomes have great potential in the diagnosis and treatment of diseases, which will be the focus of future research.
- Exosomes /
- Non-Alcoholic Fatty Liver Disease /
- Liver Diseases

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参考文献(36)

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