Mechanism and treatment of portal-systemic circulatory imbalance in hepatorenal syndrome
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摘要: 肝肾综合征是终末期肝病的严重并发症,其发生与门静脉高压、动脉血管扩张、心输出量和有效循环血量减少、肾动脉收缩等全身血流动力学改变,以及门体循环失衡相关。对于肝肾综合征的治疗,目前主要采用血管活性药物、介入等手段改变全身血流动力学、门体循环失衡,及早干预可改善患者预后。Abstract: Hepatorenal syndrome (HRS) is a serious complication of end-stage liver disease, and its pathogenesis is associated with the systemic hemodynamic changes such as portal hypertension, arterial vasodilation, reduced cardiac output, reduced effective circulating blood volume, and renal artery contraction, as well as portal-systemic circulatory imbalance. For the treatment of HRS at present, vasoactive agents and interventional treatment are used to change systemic hemodynamics and portal-systemic circulatory imbalance, and early intervention can improve the prognosis of patients.
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Key words:
- Hepatorenal Syndrome /
- Portal Hypertension /
- Blood Circulatione /
- Therapeutics
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